Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 11/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | GRM5 | P41594 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9159704 | 0.89 | KMT2A (0.41) | ALOX5MCHR1KCNH2NPC1RAB9A | |
| SCHEMBL9155027 | 0.89 | MRGPRX4 (0.37) | ALOX5MCHR1KCNH2CYP2D6HRH3 | |
| SCHEMBL9159373 | 0.88 | ALOX5 (0.49) | ALOX5CYP2D6HRH3NPC1RAB9A | |
| SCHEMBL9158037 | 0.85 | KMT2A (0.41) | ALOX5NPC1RAB9AKMT2AMAOB | |
| SCHEMBL9160895 | 0.85 | MAOB (0.38) | ALOX5NPC1RAB9AMAOBGRM5 | |
| SCHEMBL9160911 | 0.79 | MEN1 (0.44) | ALOX5NPC1RAB9AMEN1KMT2A | |
| SCHEMBL9263722 | 0.78 | NPC1 (0.58) | NPC1RAB9AMEN1KMT2AMAOB | |
| SCHEMBL9161622 | 0.78 | MAOB (0.39) | ALOX5MCHR1KCNH2NPC1RAB9A | |
| SCHEMBL9156981 | 0.78 | F10 (0.41) | ALOX5NPC1RAB9AMEN1KMT2A | |
| SCHEMBL9158135 | 0.77 | ALOX5 (0.42) | ALOX5NPC1RAB9AMAOBGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5410054-A | Heteroaryl quinolines as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1995-04-25 | — | — | US | disclosed |
| WO-1995003300-A1 | HETEROARYL QUINOLINES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC. (CA) | 1995-02-02 | — | — | WO | disclosed |