Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 9/20 | 0.39 |
| ▸ | CA12 | O43570 | 3/20 | 0.38 |
| ▸ | CA9 | Q16790 | 3/20 | 0.38 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.36 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9158037 | 0.94 | KMT2A (0.41) | KMT2AALOX5CA12CA9NPC1 | |
| SCHEMBL9156479 | 0.89 | ALOX5 (0.38) | KMT2AALOX5CA12CA9MEN1 | |
| SCHEMBL9159373 | 0.89 | ALOX5 (0.49) | KMT2AALOX5MEN1NPC1RAB9A | |
| SCHEMBL9156981 | 0.89 | F10 (0.41) | KMT2AALOX5F10MEN1NPC1 | |
| SCHEMBL9160911 | 0.86 | MEN1 (0.44) | KMT2AALOX5CA12CA9MEN1 | |
| SCHEMBL9158135 | 0.85 | ALOX5 (0.42) | ALOX5CA12CA9NPC1RAB9A | |
| SCHEMBL9155047 | 0.81 | ALOX5 (0.52) | ALOX5CA12CA9 | |
| SCHEMBL9157666 | 0.80 | ALOX5 (0.39) | ALOX5CA12CA9NPC1RAB9A | |
| SCHEMBL9263722 | 0.79 | NPC1 (0.58) | KMT2ACA12CA9MEN1NPC1 | |
| SCHEMBL9161622 | 0.79 | MAOB (0.39) | ALOX5NPC1RAB9AMAOBGRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5410054-A | Heteroaryl quinolines as inhibitors of leukotriene biosynthesis | MERCK FROSST CANADA, INC. (CA) | 1995-04-25 | — | — | US | disclosed |
| WO-1995003300-A1 | HETEROARYL QUINOLINES AS INHIBITORS OF LEUKOTRIENE BIOSYNTHESIS | MERCK FROSST CANADA INC. (CA) | 1995-02-02 | — | — | WO | disclosed |