Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.41 |
| ▸ | CA12 | O43570 | 2/20 | 0.41 |
| ▸ | CA1 | P00915 | 2/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | S100B | P04271 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.35 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9160469 | 0.86 | CA9 (0.50) | ESR1CA9CA12CA1CA2 | |
| SCHEMBL13460950 | 0.81 | ESR1 (0.55) | ESR1CA9CA12CA1CA2 | |
| SCHEMBL29906097 | 0.81 | ESR1 (0.55) | ESR1CA9CA12CA1CA2 | |
| SCHEMBL13416893 | 0.81 | MAPK1 (0.48) | ESR1CA9CA12CA1MAPK1 | |
| SCHEMBL13416775 | 0.81 | MAPK1 (0.48) | ESR1CA9CA12CA1MAPK1 | |
| SCHEMBL728758 | 0.79 | POLB (0.54) | ESR1CA9CA12CA1MAPK1 | |
| SCHEMBL818923 | 0.79 | MAPK1 (0.49) | ESR1CA9CA12CA1MAPK1 | |
| SCHEMBL9277775 | 0.78 | ESR1 (0.43) | ESR1CA9CA12CA1CA2 | |
| SCHEMBL24380215 | 0.78 | ESR1 (0.49) | ESR1CA9CA12CA1CA2 | |
| SCHEMBL23380194 | 0.78 | ESR1 (0.42) | ESR1CA9CA12CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0402632-B1 | Aromatic polyimide silanol compounds, precursors and polymers thereof | HUGHES AIRCRAFT CO (US) | 1995-03-08 | — | — | EP | disclosed |
| US-5081201-A | Protective coatings | HUGHES AIRCRAFT COMPANY (US) | 1992-01-14 | — | — | US | disclosed |
| US-5075475-A | Monomer for polyimidosiloxane copolymer | HUGHES AIRCRAFT COMPANY (US) | 1991-12-24 | — | — | US | disclosed |
| US-5021585-A | Engineering thermoplastics; good optics, heat and oxidation resistance | HUGHES AIRCRAFT COMPANY (US) | 1991-06-04 | — | — | US | disclosed |