Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | MGMT | P16455 | 1/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.37 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.37 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27692387 | 0.80 | GAA (0.46) | GAAALDH1A1GABRA1GABRG2GABRB3 | |
| SCHEMBL10806454 | 0.77 | GAA (0.46) | GAAALDH1A1GABRA1GABRG2GABRB3 | |
| SCHEMBL933699 | 0.74 | BCAT2 (0.55) | GAABCAT2ALDH1A1MAPTHTT | |
| SCHEMBL7637514 | 0.72 | GAA (0.49) | GAAALDH1A1GABRA1GABRG2GABRB3 | |
| SCHEMBL8966043 | 0.72 | BCAT2 (0.41) | BCAT2ALDH1A1MGMTGABRA1GABRG2 | |
| SCHEMBL8816431 | 0.70 | GAA (1.00) | GAAALDH1A1SLC1A3SLC1A2SLC1A1 | |
| SCHEMBL1927812 | 0.70 | GAA (0.46) | GAAALDH1A1MGMTGABRA1GABRG2 | |
| SCHEMBL8965572 | 0.70 | SYK (0.47) | BCAT2ALDH1A1MGMT | |
| SCHEMBL4937651 | 0.70 | LOXL2 (0.53) | GAAALDH1A1MAPK1TDP1 | |
| SCHEMBL23456206 | 0.69 | GAA (0.57) | GAAALDH1A1MGMTSLC1A3SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5380759-A | Methyl N-[6-(3,4,5-trimethoxybenzloxy)imidazo[1,2-b]pyridazin-2-zyl]carbamate used to treat leukemia | BURROUGHS WELLCOME CO. (US) | 1995-01-10 | — | — | US | disclosed |
| US-5371219-A | Antitumor agents | BURROUGHS WELLCOME CO. (US) | 1994-12-06 | — | — | US | disclosed |