Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 1/20 | 0.74 |
| ▸ | NPC1 | O15118 | 1/20 | 0.68 |
| ▸ | RAB9A | P51151 | 1/20 | 0.68 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.67 |
| ▸ | PIK3CA | P42336 | 4/20 | 0.67 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.67 |
| ▸ | IGF1R | P08069 | 1/20 | 0.59 |
| ▸ | KDR | P35968 | 3/20 | 0.59 |
| ▸ | FLT1 | P17948 | 2/20 | 0.59 |
| ▸ | FLT4 | P35916 | 2/20 | 0.59 |
| ▸ | SYK | P43405 | 3/20 | 0.58 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.57 |
| ▸ | CDK2 | P24941 | 3/20 | 0.55 |
| ▸ | GSK3B | P49841 | 2/20 | 0.55 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.55 |
| ▸ | CDK4 | P11802 | 1/20 | 0.55 |
| ▸ | CDK5 | Q00535 | 3/20 | 0.55 |
| ▸ | CDC7 | O00311 | 1/20 | 0.55 |
| ▸ | PLK4 | O00444 | 1/20 | 0.55 |
| ▸ | IKBKB | O14920 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1377802 | 0.85 | EGFR (1.00) | EGFRNPC1RAB9APIK3CGPIK3CA | |
| SCHEMBL2284267 | 0.84 | EGFR (0.72) | EGFRNPC1RAB9APIK3CGPIK3CA | |
| SCHEMBL15185760 | 0.83 | IGF1R (0.62) | EGFRNPC1RAB9APIK3CGPIK3CA | |
| SCHEMBL2324992 | 0.83 | PIK3CG (0.76) | EGFRNPC1RAB9APIK3CGPIK3CA | |
| Hydrochloric Acid SCHEMBL12813301 | 0.83 | EGFR (0.71) | EGFRNPC1RAB9APIK3CGPIK3CA | |
| SCHEMBL27116598 | 0.82 | PIK3CG (0.83) | EGFRNPC1RAB9APIK3CGPIK3CA | |
| SCHEMBL84484 | 0.82 | EGFR (0.69) | EGFRPIK3CGPIK3CAPIK3CBIGF1R | |
| SCHEMBL31046394 | 0.82 | EGFR (0.92) | EGFRNPC1RAB9APIK3CGPIK3CA | |
| SCHEMBL14618917 | 0.81 | MEN1 (0.71) | NPC1RAB9APIK3CGPIK3CAPIK3CB | |
| SCHEMBL14088797 | 0.81 | PIK3CA (0.62) | EGFRPIK3CGPIK3CAPIK3CBKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8865732-B2 | Heterocyclic compounds and uses thereof | NOVARTIS AG (CH) | 2014-10-21 | — | — | US | disclosed |
| US-20130210818-A1 | Novel Heterocyclic Compounds and Uses Thereof | NOVARTIS AG (CH) | 2013-08-15 | — | — | US | disclosed |
| US-8129394-B2 | Heteroaryl-substituted imidazole compounds and uses thereof | NOVARTIS AG (CH) | 2012-03-06 | — | — | US | disclosed |
| US-20100003246-A1 | Novel heterocyclic compounds and uses therof | NOVARTIS AG (CH) | 2010-01-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100003246-A1 | Novel heterocyclic compounds and uses therof | BRAF, ARAF, KRAS | EGFR 197/4885NPC1 4113/4885RAB9A 1118/4885 |
| US-20130210818-A1 | Novel Heterocyclic Compounds and Uses Thereof | BRAF, RAF1, HRAS | EGFR 782/4885NPC1 3321/4885RAB9A 1078/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.