Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 4/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | USP2 | O75604 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | RARB | P10826 | 7/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | RARA | P10276 | 2/20 | 0.48 |
| ▸ | RARG | P13631 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | STAT3 | P40763 | 1/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9155593 | 1.00 | MAPT (0.53) | MAPTRAB9AHSD17B10ALDH1A1KDM4E | |
| SCHEMBL9161133 | 0.98 | MAPT (0.55) | MAPTRAB9AHSD17B10ALDH1A1KDM4E | |
| SCHEMBL9157460 | 0.98 | MAPT (0.55) | MAPTRAB9AHSD17B10ALDH1A1KDM4E | |
| SCHEMBL9153776 | 0.98 | MAPT (0.55) | MAPTRAB9AHSD17B10ALDH1A1KDM4E | |
| SCHEMBL9152381 | 0.98 | MAPT (0.55) | MAPTRAB9AHSD17B10ALDH1A1KDM4E | |
| SCHEMBL9160174 | 0.95 | RARB (0.47) | MAPTRAB9AHSD17B10ALDH1A1KDM4E | |
| SCHEMBL9161126 | 0.95 | RARB (0.47) | MAPTRAB9AHSD17B10ALDH1A1KDM4E | |
| SCHEMBL9157693 | 0.92 | RAB9A (0.52) | MAPTRAB9AHSD17B10ALDH1A1KDM4E | |
| SCHEMBL9766634 | 0.90 | MAPT (0.48) | MAPTRAB9AHSD17B10ALDH1A1KDM4E | |
| SCHEMBL9158742 | 0.88 | CYP2A6 (0.44) | MAPTRAB9AHSD17B10ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445248-B1 | PYRIDINE DERIVATIVES | MERCK PATENT GMBH (DE) | 1995-03-08 | — | — | EP | disclosed |
| US-5205962-A | Stable liquid crystals | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-04-27 | — | — | US | disclosed |
| WO-1991004248-A1 | PYRIDINE DERIVATIVES | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1991-04-04 | — | — | WO | disclosed |