Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB1 | P08183 | 7/20 | 0.40 |
| ▸ | PGR | P06401 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.38 |
| ▸ | ABCC9 | O60706 | 3/20 | 0.38 |
| ▸ | ABCC8 | Q09428 | 2/20 | 0.38 |
| ▸ | KCNJ11 | Q14654 | 2/20 | 0.38 |
| ▸ | KCNJ8 | Q15842 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.37 |
| ▸ | CHRNG | P07510 | 1/20 | 0.37 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.37 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.37 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.37 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.37 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9160473 | 0.81 | KDM1A (0.44) | ABCB1PGRKDM1ACYP11B2ABCC9 | |
| SCHEMBL9158928 | 0.81 | PGR (0.53) | ABCB1PGRKDM1ACYP11B2ABCC9 | |
| SCHEMBL9032284 | 0.74 | ABCB1 (0.46) | ABCB1ABCC9ABCC8KCNJ11KCNJ8 | |
| SCHEMBL25444478 | 0.71 | KDM1A (0.48) | ABCB1PGRKDM1ACYP11B2ABCC9 | |
| SCHEMBL10512412 | 0.71 | PGR (0.60) | ABCB1PGRKDM1ACYP11B2ABCC9 | |
| SCHEMBL11744995 | 0.70 | HTR2C (0.38) | CYP2D6CYP2C19 | |
| SCHEMBL16905203 | 0.68 | PGR (0.42) | ABCB1PGRKDM1ACYP11B2NSD2 | |
| SCHEMBL2223445 | 0.68 | RARB (0.53) | PGRKDM1ANSD2DRD2DRD3 | |
| SCHEMBL17771666 | 0.66 | XIAP (0.46) | ABCB1PGRNSD2DRD2DRD3 | |
| SCHEMBL24489941 | 0.65 | ABCB1 (0.36) | ABCB1ABCC9ABCC8KCNJ11KCNJ8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5401848-A | Indane and quinoline derivatives | E. R. SQUIBB & SONS, INC. (US) | 1995-03-28 | — | — | US | disclosed |
| EP-0488616-A1 | Indane and quinoline derivatives | E.R. SQUIBB & SONS, INC. (US) | 1992-06-03 | — | — | EP | disclosed |