Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | FAAH | O00519 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9425466 | 0.86 | MEN1 (0.40) | MEN1FAAHMAPK1KMT2A | |
| SCHEMBL24942562 | 0.84 | MEN1 (0.47) | MEN1FAAHMAPK1KMT2AEPHX1 | |
| SCHEMBL9425761 | 0.78 | MEN1 (0.44) | MEN1FAAHMAPK1KMT2A | |
| SCHEMBL19312859 | 0.77 | CA12 (0.43) | MEN1FAAHMAPK1KMT2AEPHX1 | |
| SCHEMBL7459318 | 0.73 | KDM5A (0.49) | MEN1FAAHKMT2ACA12CA1 | |
| SCHEMBL25412745 | 0.73 | KDM5A (0.49) | MEN1FAAHKMT2ACA12CA1 | |
| SCHEMBL25318796 | 0.73 | KDM5A (0.49) | MEN1FAAHKMT2ACA12CA1 | |
| SCHEMBL20536250 | 0.73 | KDM5A (0.49) | MEN1FAAHKMT2ACA12CA1 | |
| SCHEMBL25318391 | 0.73 | KDM5A (0.49) | MEN1FAAHKMT2ACA12CA1 | |
| SCHEMBL25235788 | 0.73 | KDM5A (0.49) | MEN1FAAHKMT2ACA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5478830-A | Pyrazolo pyrimidines; inhibitors of acyl-coenzyme A and cholesterol acyltransferase; antihypercholesterolemic agents | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1995-12-26 | — | — | US | disclosed |
| US-5290801-A | Anticholesterol or antilipemic agents | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-03-01 | — | — | US | disclosed |