Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | SLC13A5 | Q86YT5 | 6/20 | 0.36 |
| ▸ | MMP8 | P22894 | 2/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.32 |
| ▸ | HMGCR | P04035 | 1/20 | 0.32 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL27835074 | 0.83 | ALDH1A1 (0.83) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL28991913 | 0.81 | ALDH1A1 (0.79) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL6731419 | 0.81 | ALDH1A1 (0.79) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL27753294 | 0.81 | ALDH1A1 (0.58) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL29034735 | 0.80 | ALDH1A1 (0.52) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL11316130 | 0.79 | ALDH1A1 (0.56) | ALDH1A1KDM4EMAPTSLC13A5 | |
| Citric Acid SCHEMBL28058231 | 0.77 | ALDH1A1 (0.71) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL7155667 | 0.76 | ALDH1A1 (0.88) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL1243199 | 0.76 | ALDH1A1 (0.88) | ALDH1A1KDM4ELMNAMAPTALOX15 | |
| Citric Acid SCHEMBL6838001 | 0.76 | ALDH1A1 (0.88) | ALDH1A1KDM4ELMNAMAPTALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 22 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456614-A | Preparation method of chromium copper chromium circuit substrate | 江西荣晖电子有限公司 | 2023-07-18 | — | — | CN | claimed |
| CN-102303199-B | Soldering flux composition containing cyclohexane citrate | Guangzhou chemical reagent factory | 2012-08-01 | — | — | CN | claimed |
| CN-102296297-B | Aqueous metal anti-rust agent | Guangzhou chemical reagent factory | 2012-07-18 | — | — | CN | claimed |
| CN-102303199-A | Soldering flux composition containing cyclohexane citrate | Guangzhou chemical reagent factory | 2012-01-04 | — | — | CN | claimed |
| CN-102296297-A | Aqueous metal anti-rust agent | — | 2011-12-28 | — | — | CN | claimed |
| US-4753736-A | USING AQUEOUS SOLUTION OF CITRATE SALT OF VOLATILE AMINE | BETZ LABORATORIES, INC. (US) | 1988-06-28 | — | — | US | claimed |
| US-4290812-A | Process for the production of inks free of foreign salts | OLYMPIA WERKE AG (DE) | 1981-09-22 | — | — | US | claimed |
| CN-116604222-A | Environment-friendly cleaning-free water-based scaling powder for series welding of photovoltaic modules and preparation method thereof | 杭州正盟环保工程有限公司 | 2023-08-18 | — | — | CN | disclosed |
| CN-116456614-A | Preparation method of chromium copper chromium circuit substrate | 江西荣晖电子有限公司 | 2023-07-18 | — | — | CN | disclosed |
| CN-108103511-B | Water-based antirust agent for small-modulus gear and preparation method of water-based antirust agent | 马鞍山金泉工业介质科技有限公司 | 2020-01-17 | — | — | CN | disclosed |
| CN-108103511-A | A kind of fine module gear water-based antirust agent and preparation method thereof | 马鞍山金泉工业介质科技有限公司 | 2018-06-01 | — | — | CN | disclosed |
| CN-104357850-A | Metal surface antirust solution and preparation method thereof | WUXI EPIC TECHNOLOGY CO LTD | 2015-02-18 | — | — | CN | disclosed |
| CN-102303199-B | Soldering flux composition containing cyclohexane citrate | Guangzhou chemical reagent factory | 2012-08-01 | — | — | CN | disclosed |
| CN-102303199-A | Soldering flux composition containing cyclohexane citrate | Guangzhou chemical reagent factory | 2012-01-04 | — | — | CN | disclosed |
| CN-102296297-A | Aqueous metal anti-rust agent | — | 2011-12-28 | — | — | CN | disclosed |
| CN-102296297-A | Aqueous metal anti-rust agent | — | 2011-12-28 | — | — | CN | disclosed |
| US-5389261-A | Water treatment, regeneration of cation exchange resin by passing through an aqueous solution of an organic salt of low volatility amine, corrosion inhibitor | GRACE DEARBORN INC. (CA) | 1995-02-14 | — | — | US | disclosed |
| US-4753736-A | USING AQUEOUS SOLUTION OF CITRATE SALT OF VOLATILE AMINE | BETZ LABORATORIES, INC. (US) | 1988-06-28 | — | — | US | disclosed |
| US-4753736-A | USING AQUEOUS SOLUTION OF CITRATE SALT OF VOLATILE AMINE | BETZ LABORATORIES, INC. (US) | 1988-06-28 | — | — | US | disclosed |
| US-4290812-A | Process for the production of inks free of foreign salts | OLYMPIA WERKE AG (DE) | 1981-09-22 | — | — | US | disclosed |