Known targets — ChEMBL curated mechanism
ACVR1ADORA1ADORA2AADORA2BADORA3ESR1ESR2FLT3GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSC1HRH1HTR7IDH1IDH2IRAK1JAK1JAK2JAK3MEN1OPRM1P2RX3PDE5ASCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASIGMAR1SLC6A2SYKTACR1TOP2ATYK2
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.36 |
| ▸ | GRM3 | Q14832 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 3/20 | 0.35 |
| ▸ | PHF8 | Q9UPP1 | 3/20 | 0.35 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | METAP1 | P53582 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL16834351 | 0.90 | SIGMAR1 (0.50) | ALDH1A1SIGMAR1CYP2D6GRM2GRM3 | |
| Citric Acid SCHEMBL23044018 | 0.82 | ALDH1A1 (0.56) | ALDH1A1HPGDKDM5APHF8KDM2A | |
| Bicarbonate SCHEMBL9362981 | 0.81 | SIGMAR1 (0.52) | ALDH1A1SIGMAR1CHRM2CHRM1CHRM3 | |
| Citric Acid SCHEMBL9159540 | 0.80 | ALDH1A1 (0.58) | ALDH1A1CHRM2CHRM1CHRM3CYP2D6 | |
| Citric Acid SCHEMBL27835074 | 0.79 | ALDH1A1 (0.83) | ALDH1A1CHRM1CYP2D6LMNAKDM4E | |
| Acetic Acid SCHEMBL435529 | 0.77 | SIGMAR1 (0.48) | ALDH1A1SIGMAR1CHRM2CHRM1CHRM3 | |
| Citric Acid SCHEMBL28991913 | 0.77 | ALDH1A1 (0.79) | ALDH1A1CHRM1CYP2D6LMNAKDM4E | |
| Citric Acid SCHEMBL6731419 | 0.77 | ALDH1A1 (0.79) | ALDH1A1CHRM1CYP2D6LMNAKDM4E | |
| Citric Acid SCHEMBL1860783 | 0.77 | ALDH1A1 (0.79) | ALDH1A1CHRM1CYP2D6LMNAKDM4E | |
| Citric Acid SCHEMBL27753294 | 0.77 | ALDH1A1 (0.58) | ALDH1A1GRM2GRM3LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116456614-A | Preparation method of chromium copper chromium circuit substrate | 江西荣晖电子有限公司 | 2023-07-18 | — | — | CN | disclosed |