Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.62 |
| ▸ | PLA2G4B | P0C869 | 8/20 | 0.61 |
| ▸ | PLA2G4A | P47712 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | TSHR | P16473 | 1/20 | 0.61 |
| ▸ | PPARD | Q03181 | 1/20 | 0.60 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.59 |
| ▸ | RARB | P10826 | 3/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15145792 | 0.95 | PPARD (0.65) | MEN1ALDH1A1KMT2APLA2G4BPLA2G4A | |
| SCHEMBL810018 | 0.87 | PPARD (0.53) | MEN1ALDH1A1KMT2APLA2G4BPPARD | |
| SCHEMBL10961443 | 0.85 | TP53 (0.60) | PLA2G4BPLA2G4ATP53TSHRRARB | |
| SCHEMBL31473503 | 0.84 | PLA2G4B (0.63) | ALDH1A1PLA2G4BTP53TSHRNR5A1 | |
| SCHEMBL10757136 | 0.84 | PLA2G4B (0.63) | ALDH1A1PLA2G4BTP53TSHRNR5A1 | |
| SCHEMBL12869161 | 0.84 | ALDH1A1 (0.63) | MEN1ALDH1A1KMT2APLA2G4APPARD | |
| SCHEMBL9160866 | 0.84 | PLA2G4B (0.63) | ALDH1A1PLA2G4BTP53TSHRNR5A1 | |
| SCHEMBL14125946 | 0.84 | PLA2G4B (0.63) | ALDH1A1PLA2G4BTP53TSHRNR5A1 | |
| SCHEMBL7280156 | 0.84 | PLA2G4B (0.63) | ALDH1A1PLA2G4BTP53TSHRNR5A1 | |
| SCHEMBL2632219 | 0.84 | PLA2G4B (0.63) | ALDH1A1PLA2G4BTP53TSHRNR5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5432189-A | Bis-aryl amide and urea antagonists of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1995-07-11 | — | — | US | disclosed |
| US-5350759-A | Bis-aryl urea compounds | WISSNER ALLAN (US) | 1994-09-27 | — | — | US | disclosed |
| US-5328921-A | Antagonist of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1994-07-12 | — | — | US | disclosed |
| US-5231182-A | Platelet activating factor inhibitor | AMERICAN CYANAMID COMPANY (US) | 1993-07-27 | — | — | US | disclosed |
| US-5225425-A | Respiratory system disorders | AMERICAN CYANAMID COMPANY (US) | 1993-07-06 | — | — | US | disclosed |
| US-5208247-A | Antianaphylactic agents or septic shock | AMERICAN CYANAMID COMPANY (US) | 1993-05-04 | — | — | US | disclosed |
| EP-0530444-A1 | Aryl, amide, imide, and carbamate pyridine antagonists of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1993-03-10 | — | — | EP | disclosed |
| US-5128351-A | BIS-ARYL AMIDE AND UREA ANTAGONISTS OF PLATELET ACTIVATING FACTOR | AMERICAN CYANAMID COMPANY (US) | 1992-07-07 | — | — | US | disclosed |
| US-5077409-A | Reducing hydroxy bis-aryl amide, acylating, hydrolyzing, sulfonating, halogenating, alkylating with nitrogen heterocycle | AMERICAN CYANAMID COMPANY (US) | 1991-12-31 | — | — | US | disclosed |
| EP-0458037-A1 | Bis-aryl amide and urea antagonists of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1991-11-27 | — | — | EP | disclosed |