Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 18/20 | 0.67 |
| ▸ | TP53 | P04637 | 3/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.67 |
| ▸ | MEN1 | O00255 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.67 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.57 |
| ▸ | PNMT | P11086 | 1/20 | 0.56 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.56 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.55 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.55 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.55 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.55 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.55 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4760458 | 0.89 | SIGMAR1 (0.59) | SIGMAR1TP53CYP1A2MEN1ALDH1A1 | |
| SCHEMBL9158810 | 0.84 | CYP1A2 (0.57) | SIGMAR1TP53CYP1A2MEN1ALDH1A1 | |
| SCHEMBL14149704 | 0.84 | SIGMAR1 (0.71) | SIGMAR1TP53CYP1A2MEN1ALDH1A1 | |
| SCHEMBL9160584 | 0.82 | AOC3 (0.58) | SIGMAR1TP53CYP1A2MEN1ALDH1A1 | |
| SCHEMBL2538061 | 0.81 | SIGMAR1 (0.58) | SIGMAR1TP53CYP1A2MEN1ALDH1A1 | |
| SCHEMBL2830423 | 0.80 | SIGMAR1 (1.00) | SIGMAR1TP53CYP1A2MEN1ALDH1A1 | |
| SCHEMBL5681292 | 0.80 | SIGMAR1 (1.00) | SIGMAR1TP53CYP1A2MEN1ALDH1A1 | |
| SCHEMBL31497388 | 0.79 | PNMT (0.73) | SIGMAR1TP53CYP1A2MEN1ALDH1A1 | |
| SCHEMBL4714764 | 0.79 | PNMT (0.73) | SIGMAR1TP53CYP1A2MEN1ALDH1A1 | |
| Bromide SCHEMBL1780137 | 0.79 | SIGMAR1 (0.97) | SIGMAR1TP53CYP1A2MEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5430059-A | Treating heart disease | EISAI CO., LTD. (JP) | 1995-07-04 | — | — | US | disclosed |
| EP-0399358-B1 | Butenoic acid derivatives | EISAI CO LTD (JP) | 1995-03-08 | — | — | EP | disclosed |
| EP-0633248-A1 | Butenoic acid derivatives | Eisai Co., Ltd. (JP) | 1995-01-11 | — | — | EP | disclosed |
| EP-0589491-A1 | Butenoic acid derivatives | Eisai Co., Ltd. (JP) | 1994-03-30 | — | — | EP | disclosed |
| US-5292770-A | Butenoic acid derivatives | EISAI CO., LTD. (JP) | 1994-03-08 | — | — | US | disclosed |
| US-5166188-A | Cardiovascular disorders, antiischemic agents | EISAI CO., LTD. (JP) | 1992-11-24 | — | — | US | disclosed |
| EP-0399358-A2 | Butenoic acid derivatives | Eisai Co., Ltd. (JP) | 1990-11-28 | — | — | EP | disclosed |