Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.36 |
| ▸ | GSK3B | P49841 | 1/20 | 0.36 |
| ▸ | MGLL | Q99685 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | MAOA | P21397 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1076866 | 0.98 | KMT2A (0.42) | KMT2APOLBATMMEN1RECQL | |
| Bromide SCHEMBL1077950 | 0.97 | KMT2A (0.43) | KMT2APOLBATMMEN1RECQL | |
| Oxalic Acid SCHEMBL17395226 | 0.87 | KMT2A (0.43) | KMT2APOLBATMMEN1RECQL | |
| SCHEMBL21250472 | 0.84 | PON1 (0.43) | KMT2AMEN1CA1CA2 | |
| SCHEMBL27681815 | 0.83 | KMT2A (0.41) | KMT2APOLBATMMEN1RECQL | |
| SCHEMBL925005 | 0.79 | CA1 (0.40) | KMT2APOLBATMCA1CA2 | |
| Hydrochloric Acid SCHEMBL9661509 | 0.79 | SIGMAR1 (0.43) | KMT2AMEN1HTR1ADRD2SIGMAR1 | |
| Hydrochloric Acid SCHEMBL9661502 | 0.79 | SIGMAR1 (0.41) | KMT2AMEN1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL6115226 | 0.78 | CA1 (0.40) | KMT2APOLBATMCA1CA2 | |
| SCHEMBL925001 | 0.76 | KMT2A (0.46) | KMT2APOLBATMMEN1CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0552292-B1 | SUBSTITUTED IMIDAZOBENZAZEPINES AND IMIDAZOPYRIDOAZEPINES | SCHERING CORP (US) | 1995-06-21 | — | — | EP | disclosed |
| US-5393753-A | Antiallergens, antiinflammatory agents | SCHERING CORPORATION (US) | 1995-02-28 | — | — | US | disclosed |