Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 4/20 | 0.37 |
| ▸ | DRD2 | P14416 | 3/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9233122 | 0.93 | OPRM1 (0.42) | MAOBOPRM1TMEM97SIGMAR1NOS2 | |
| SCHEMBL9160192 | 0.92 | CYP3A4 (0.38) | MAOBDRD3DRD2OPRM1TMEM97 | |
| SCHEMBL9159994 | 0.92 | MAOB (0.40) | MAOBTBXAS1SIGMAR1 | |
| SCHEMBL8828195 | 0.91 | OPRM1 (0.44) | MAOBOPRM1TMEM97SIGMAR1NOS2 | |
| SCHEMBL9160871 | 0.89 | CCR3 (0.36) | DRD3DRD2OPRM1TMEM97SIGMAR1 | |
| SCHEMBL9231352 | 0.88 | DRD3 (0.45) | MAOBDRD3DRD2TBXAS1MAPK8 | |
| SCHEMBL9159739 | 0.88 | MAOB (0.42) | MAOBTBXAS1TMEM97SIGMAR1 | |
| SCHEMBL9158719 | 0.87 | DRD3 (0.46) | DRD3DRD2 | |
| SCHEMBL9155730 | 0.87 | DRD3 (0.42) | MAOBDRD3DRD2MAPK8MAPK10 | |
| SCHEMBL8828419 | 0.86 | MAOB (0.38) | MAOBDRD3DRD2OPRM1TMEM97 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5430059-A | Treating heart disease | EISAI CO., LTD. (JP) | 1995-07-04 | — | — | US | disclosed |
| EP-0633248-A1 | Butenoic acid derivatives | Eisai Co., Ltd. (JP) | 1995-01-11 | — | — | EP | disclosed |
| EP-0589491-A1 | Butenoic acid derivatives | Eisai Co., Ltd. (JP) | 1994-03-30 | — | — | EP | disclosed |
| US-5292770-A | Butenoic acid derivatives | EISAI CO., LTD. (JP) | 1994-03-08 | — | — | US | disclosed |
| US-5166188-A | Cardiovascular disorders, antiischemic agents | EISAI CO., LTD. (JP) | 1992-11-24 | — | — | US | disclosed |
| EP-0399358-A2 | Butenoic acid derivatives | Eisai Co., Ltd. (JP) | 1990-11-28 | — | — | EP | disclosed |