Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4132207 | 0.84 | RECQL (0.56) | RECQLKDM4EABL1KCNMA1 | |
| SCHEMBL635552 | 0.84 | RECQL (0.56) | RECQLKDM4EABL1KCNMA1LMNA | |
| SCHEMBL27713896 | 0.81 | MAPT (0.76) | MAPTTDP1RECQLKDM4EHPGD | |
| SCHEMBL4118699 | 0.81 | RECQL (0.46) | MAPTRECQLABL1LMNAMAPK1 | |
| SCHEMBL6233142 | 0.80 | TUBB4A (0.57) | MAPTLMNA | |
| SCHEMBL2705425 | 0.79 | RECQL (0.65) | MAPTRECQLKDM4EKCNMA1LMNA | |
| SCHEMBL2705487 | 0.78 | POLB (0.66) | MAPTRECQLHPGDLMNAHSD17B10 | |
| SCHEMBL2705226 | 0.78 | NPC1 (0.56) | MAPTRECQLHPGDLMNA | |
| SCHEMBL4125266 | 0.77 | RECQL (0.57) | RECQLKDM4EABL1KCNMA1 | |
| SCHEMBL8134079 | 0.77 | CYP1A2 (0.58) | MAPTRECQLLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0354994-B1 | Quinoline derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1995-01-25 | — | — | EP | disclosed |
| US-5254565-A | Enzyme inhibitors; anticholesterol agents | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1993-10-19 | — | — | US | disclosed |