Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | KIF11 | P52732 | 1/20 | 0.40 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.39 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | GALR3 | O60755 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CCNC | P24863 | 1/20 | 0.37 |
| ▸ | CDK8 | P49336 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2732089 | 0.79 | LMNA (0.50) | LMNATDP1CHRNB2CHRNA4KMT2A | |
| SCHEMBL29583666 | 0.79 | LMNA (0.50) | LMNATDP1CHRNB2CHRNA4KMT2A | |
| SCHEMBL2401039 | 0.79 | LMNA (0.43) | LMNATDP1CHRNB2CHRNA4KMT2A | |
| SCHEMBL27983764 | 0.77 | CHRNB2 (0.50) | LMNATDP1CHRNB2CHRNA4CYP11B1 | |
| SCHEMBL6210928 | 0.77 | CA4 (0.39) | LMNATDP1ALDH1A1KMT2AMAPK1 | |
| SCHEMBL3372165 | 0.74 | PPARA (0.50) | ALDH1A1THRBKMT2A | |
| SCHEMBL26146529 | 0.73 | LMNA (0.44) | LMNATDP1CHRNB2CHRNA4KMT2A | |
| SCHEMBL28206059 | 0.72 | KMT2A (0.54) | LMNATDP1CHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL7099252 | 0.71 | CHRNB2 (0.45) | LMNATDP1CHRNB2CHRNA4CYP11B1 | |
| SCHEMBL130691 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1040753-C | Pyridine derivatives and the preparation thereof | ICI PLC (GB) | 1998-11-18 | — | — | CN | disclosed |
| US-5401849-A | FOR ANTAGONIZING THE ACTIONS OF, AND INHIBITING THE SYNTHESIS OF, THROMBOXANE A2 | ZENECA LIMITED (GB) | 1995-03-28 | — | — | US | disclosed |
| EP-0329360-B1 | Pyridine derivatives | ICI PLC (GB) | 1994-08-03 | — | — | EP | disclosed |
| US-5248780-A | Thromboxane inhibitors | IMPERIAL CHEMICAL INDUSTRIES, PLC (GB) | 1993-09-28 | — | — | US | disclosed |
| US-5166213-A | Antiischemic agents, cardiovascular disorders, antiasthmatics or antiinflammatory agents | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-11-24 | — | — | US | disclosed |
| EP-0288279-B1 | 1,3-DIOXANES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-09-09 | — | — | EP | disclosed |
| CN-1015893-B | 1,3-DIOXANES | ICI LTD (GB) | 1992-03-18 | — | — | CN | disclosed |
| US-4921866-A | 1,3-dioxanes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1990-05-01 | — | — | US | disclosed |
| CN-1035115-A | Pyridine derivate and preparation method thereof | ICI PLC (GB) | 1989-08-30 | — | — | CN | disclosed |
| EP-0329360-A2 | Pyridine derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-08-23 | — | — | EP | disclosed |
| CN-88102356-A | 1,3-two alkanes | — | 1988-12-28 | — | — | CN | disclosed |
| EP-0288279-A2 | 1,3-Dioxanes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1988-10-26 | — | — | EP | disclosed |