Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | RIN1 | Q13671 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | GBA1 | P04062 | 1/20 | 0.30 |
| ▸ | MMP1 | P03956 | 1/20 | 0.30 |
| ▸ | MMP3 | P08254 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9693373 | 0.91 | ADRA2A (0.35) | GAAADRA2ANISCHMEN1KMT2A | |
| SCHEMBL9597453 | 0.84 | CYP3A4 (0.36) | GAA | |
| SCHEMBL9693632 | 0.84 | GAA (0.36) | GAAADRA2ANISCHMEN1KMT2A | |
| SCHEMBL9161597 | 0.80 | GAA (0.41) | GAATP53ABL1RIN1TDP1 | |
| SCHEMBL4370549 | 0.79 | ADRA2A (0.37) | GAATP53TDP1ADRA2ANISCH | |
| SCHEMBL9693393 | 0.79 | PIK3CD (0.33) | GAAADRA2ANISCHMEN1KMT2A | |
| SCHEMBL6234518 | 0.72 | GAA (0.43) | GAATP53ABL1RIN1TDP1 | |
| SCHEMBL9693427 | 0.72 | GAA (0.35) | GAAADRA2ANISCH | |
| SCHEMBL6235193 | 0.70 | GAA (0.44) | GAATP53ABL1RIN1TDP1 | |
| SCHEMBL27082357 | 0.70 | GAA (0.47) | GAATP53ABL1RIN1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5436260-A | Substituted 1-benzylimidazole-5-methylidene hydantoins | WARNER-LAMBERT COMPANY (US) | 1995-07-25 | — | — | US | disclosed |
| US-5308853-A | Hypotensive agents, antagonists of angiotensin II | WARNER-LAMBERT COMPANY (US) | 1994-05-03 | — | — | US | disclosed |
| WO-1993013077-A1 | ANGIOTENSIN II RECEPTOR ANTAGONISTS | WARNER-LAMBERT COMPANY (US) | 1993-07-08 | — | — | WO | disclosed |
| EP-0252503-B1 | AMINOIMIDAZOQUINOLINE DERIVATIVES | Bristol-Myers Squibb Company (US) | 1992-11-19 | — | — | EP | disclosed |
| US-4775674-A | CARDIOTONIC AGENTS | BRISTOL-MYERS COMPANY (US) | 1988-10-04 | — | — | US | disclosed |
| EP-0252503-A1 | Aminoimidazoquinoline derivatives | Bristol-Myers Squibb Company (US) | 1988-01-13 | — | — | EP | disclosed |
| US-4701459-A | 7-amino-1,3-dihydro-2H-imidazo[4,5-b]quinolin 2-ones and method for inhibiting phosphodiesterase and blood platelet aggregation | BRISTOL-MYERS COMPANY (US) | 1987-10-20 | — | — | US | disclosed |
| US-4668686-A | 1,3-DIHYDRO-2H-IMIDAZO/4,5-B/QUINOLINE-2-ONES | BRISTOL-MYERS COMPANY (US) | 1987-05-26 | — | — | US | disclosed |