Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.54 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.51 |
| ▸ | IDO1 | P14902 | 2/20 | 0.49 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8727026 | 1.00 | TSHR (0.55) | TSHREPHX1KCNH2KCNJ1IDO1 | |
| SCHEMBL11308396 | 1.00 | TSHR (0.55) | TSHREPHX1KCNH2KCNJ1IDO1 | |
| SCHEMBL378396 | 0.93 | TSHR (0.58) | TSHREPHX1KCNH2KCNJ1IDO1 | |
| SCHEMBL19929796 | 0.92 | KCNH2 (0.66) | TSHREPHX1KCNH2KCNJ1CHRM2 | |
| SCHEMBL1310286 | 0.92 | KCNH2 (0.51) | TSHREPHX1KCNH2KCNJ1IDO1 | |
| SCHEMBL6696078 | 0.88 | KCNH2 (0.54) | TSHREPHX1KCNH2KCNJ1IDO1 | |
| SCHEMBL18913824 | 0.87 | TSHR (0.69) | TSHRKCNH2KCNJ1IDO1LOXL2 | |
| SCHEMBL1164057 | 0.86 | TDP1 (0.59) | TSHREPHX1KCNH2IDO1SIGMAR1 | |
| SCHEMBL1312040 | 0.85 | TSHR (0.47) | TSHREPHX1KCNH2KCNJ1IDO1 | |
| SCHEMBL3656180 | 0.85 | TSHR (0.62) | TSHRKCNH2KCNJ1IDO1LOXL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5432189-A | Bis-aryl amide and urea antagonists of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1995-07-11 | — | — | US | disclosed |
| US-5350759-A | Bis-aryl urea compounds | WISSNER ALLAN (US) | 1994-09-27 | — | — | US | disclosed |
| US-5231182-A | Platelet activating factor inhibitor | AMERICAN CYANAMID COMPANY (US) | 1993-07-27 | — | — | US | disclosed |
| US-5225425-A | Respiratory system disorders | AMERICAN CYANAMID COMPANY (US) | 1993-07-06 | — | — | US | disclosed |
| US-5128351-A | BIS-ARYL AMIDE AND UREA ANTAGONISTS OF PLATELET ACTIVATING FACTOR | AMERICAN CYANAMID COMPANY (US) | 1992-07-07 | — | — | US | disclosed |
| US-5077409-A | Reducing hydroxy bis-aryl amide, acylating, hydrolyzing, sulfonating, halogenating, alkylating with nitrogen heterocycle | AMERICAN CYANAMID COMPANY (US) | 1991-12-31 | — | — | US | disclosed |
| EP-0458037-A1 | Bis-aryl amide and urea antagonists of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1991-11-27 | — | — | EP | disclosed |