SCHEMBL91658

SCHEMBL91658

Cc1cc(C)c(-c2cc(F)c(S(F)(F)(F)(F)F)c(F)c2)c(C)c1

nearest known ligand 0.33

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
RAPGEF4 Q8WZA2 5/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL91693 0.98 RAPGEF4 (0.34) RAPGEF4
SCHEMBL91684 0.92 RAPGEF4 (0.32) RAPGEF4
SCHEMBL13087003 0.79 RAPGEF4 (0.38) RAPGEF4
SCHEMBL14075238 0.79 RAPGEF4 (0.50) RAPGEF4
SCHEMBL91762 0.78
SCHEMBL91698 0.77 KMT2A (0.35)
SCHEMBL91666 0.77 RAPGEF4 (0.34) RAPGEF4
SCHEMBL91660 0.76 RAPGEF4 (0.33) RAPGEF4
SCHEMBL91761 0.73 RAPGEF4 (0.32) RAPGEF4
SCHEMBL14075240 0.72 RAPGEF4 (0.34) RAPGEF4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8129002-B2 Compounds for use in liquid crystal media MERCK PATENT GMBH (DE) 2012-03-06 US disclosed
US-7419706-B2 Liquid crystalline medium MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) 2008-09-02 US disclosed