Known targets — ChEMBL curated mechanism
ACHECHRM1CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNG
The experimentally established mechanism targets of Iodide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | FAAH | O00519 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Iodide SCHEMBL9169587 | 0.89 | NLRP3 (0.46) | MAPTCYP2D6MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9159435 | 0.82 | CYP2D6 (0.62) | MAPTCYP2D6CYP2C19L3MBTL1GAA | |
| Hydrochloric Acid SCHEMBL9168856 | 0.81 | CYP2D6 (0.61) | MAPTCYP2D6CYP2C19L3MBTL1GAA | |
| Iodide SCHEMBL9166019 | 0.79 | SMN1; SMN2 (0.49) | MAPTCYP2D6L3MBTL1GAASMN1; SMN2 | |
| SCHEMBL9166917 | 0.76 | SMN1; SMN2 (0.59) | MAPTCYP2D6L3MBTL1GAASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL9167319 | 0.75 | MAPT (0.53) | MAPTCYP2D6L3MBTL1GAASMN1; SMN2 | |
| Iodide SCHEMBL9166006 | 0.72 | GAA (0.47) | MAPTCYP2D6MEN1KMT2AL3MBTL1 | |
| Bromide SCHEMBL9169340 | 0.72 | MAPT (0.55) | MAPTCYP2D6L3MBTL1GAASMN1; SMN2 | |
| Bromide SCHEMBL9167422 | 0.72 | MAPT (0.49) | MAPTCYP2D6L3MBTL1GAASMN1; SMN2 | |
| Bromide SCHEMBL9166550 | 0.72 | MAPT (0.49) | MAPTCYP2D6L3MBTL1GAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5432189-A | Bis-aryl amide and urea antagonists of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1995-07-11 | — | — | US | disclosed |
| US-5350759-A | Bis-aryl urea compounds | WISSNER ALLAN (US) | 1994-09-27 | — | — | US | disclosed |
| US-5231182-A | Platelet activating factor inhibitor | AMERICAN CYANAMID COMPANY (US) | 1993-07-27 | — | — | US | disclosed |
| EP-0458037-A1 | Bis-aryl amide and urea antagonists of platelet activating factor | AMERICAN CYANAMID COMPANY (US) | 1991-11-27 | — | — | EP | disclosed |