Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK1 | Q13546 | 1/20 | 0.40 |
| ▸ | KCNJ6 | P48051 | 4/20 | 0.38 |
| ▸ | KCNJ3 | P48549 | 4/20 | 0.38 |
| ▸ | KCNJ5 | P48544 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 4/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9171534 | 0.93 | IKBKB (0.34) | ALDH1A1IKBKBCCNA2CDK2CCNA1 | |
| SCHEMBL9175603 | 0.91 | IKBKB (0.41) | RIPK1KCNJ6KCNJ3KCNJ5MAPT | |
| SCHEMBL9174817 | 0.91 | RIPK1 (0.43) | RIPK1KCNJ6KCNJ3KCNJ5MAPT | |
| SCHEMBL9171500 | 0.91 | RIPK1 (0.40) | RIPK1KCNJ6KCNJ3KCNJ5MAPT | |
| SCHEMBL9174674 | 0.91 | RIPK1 (0.44) | RIPK1KCNJ6KCNJ3KCNJ5MAPT | |
| SCHEMBL9176550 | 0.90 | KMT2A (0.43) | RIPK1MAPTALDH1A1KDM4EHSD17B10 | |
| SCHEMBL9174505 | 0.89 | IKBKB (0.39) | RIPK1ALDH1A1IKBKBLMNA | |
| SCHEMBL9174664 | 0.89 | IDO1 (0.44) | RIPK1KCNJ6KCNJ3KCNJ5MAPT | |
| SCHEMBL9837095 | 0.89 | RIPK1 (0.39) | RIPK1KCNJ6KCNJ3KCNJ5MAPT | |
| SCHEMBL9836709 | 0.88 | IKBKB (0.41) | RIPK1KCNJ6KCNJ3KCNJ5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5424308-A | Immunomodulating agents | FARMITALIA CARLO ERBA S.R.L. (IT) | 1995-06-13 | — | — | US | disclosed |
| EP-0422051-A1 | CONDENSED PYRAZOLE 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.r.l. (IT) | 1991-04-17 | — | — | EP | disclosed |
| WO-1989012630-A1 | CONDENSED PYRAZOLE 3-OXO-PROPANENITRILE DERIVATIVES AND PROCESS FOR THEIR PREPARATION | FARMITALIA CARLO ERBA S.R.L. (IT) | 1989-12-28 | — | — | WO | disclosed |