Silver

Silver

SCHEMBL9166268

CCOC(=O)COc1ccc2[nH]nnc2c1C(=O)[O-].[Ag+]

nearest known ligand 0.44

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

folP

The experimentally established mechanism targets of Silver. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.44
NPSR1 Q6W5P4 4/20 0.44
HPGD P15428 4/20 0.44
KDM4E B2RXH2 4/20 0.44
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
HSD17B10 Q99714 2/20 0.44
CASP1 P29466 1/20 0.44
ESR1 P03372 1/20 0.41
GAA P10253 2/20 0.38
USP2 O75604 1/20 0.37
MAPT P10636 3/20 0.37
SMN1; SMN2 Q16637 3/20 0.37
LMNA P02545 2/20 0.37
MAPK1 P28482 2/20 0.37
TLR9 Q9NR96 2/20 0.37
NPC1 O15118 1/20 0.37
S1PR4 O95977 1/20 0.37
ITGA4 P13612 1/20 0.37
S1PR1 P21453 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6051986 0.88 ALDH1A1 (0.46) ALDH1A1NPSR1HPGDKDM4EMEN1
SCHEMBL9166266 0.87 ALDH1A1 (0.45) ALDH1A1NPSR1HPGDKDM4EMEN1
SCHEMBL6051990 0.83 ALDH1A1 (0.47) ALDH1A1NPSR1HPGDKDM4EMEN1
SCHEMBL9638029 0.82 ALDH1A1 (0.46) ALDH1A1NPSR1HPGDKDM4EMEN1
Silver SCHEMBL9167946 0.82 ALDH1A1 (0.42) ALDH1A1NPSR1HPGDKDM4EMEN1
SCHEMBL11018140 0.79 USP2 (0.46) ALDH1A1NPSR1HPGDKDM4EMEN1
SCHEMBL6052025 0.79 ALDH1A1 (0.44) ALDH1A1NPSR1HPGDKDM4EMEN1
Silver SCHEMBL9172794 0.79 KDM4E (0.35) ALDH1A1HPGDKDM4EMEN1KMT2A
SCHEMBL9167942 0.78 ALDH1A1 (0.43) ALDH1A1NPSR1HPGDKDM4EMEN1
SCHEMBL10626863 0.76 ALDH1A1 (0.41) ALDH1A1NPSR1HPGDKDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0144087-B2 Heat-developable color light-sensitive material KONISHIROKU PHOTO IND (JP) 1995-05-24 EP disclosed
EP-0174135-B2 HEAT-DEVELOPABLE COLOR LIGHT-SENSITIVE MATERIAL KONICA CORPORATION (JP) 1992-06-17 EP disclosed
EP-0144087-B1 HEAT-DEVELOPABLE COLOR LIGHT-SENSITIVE MATERIAL KONICA CORPORATION (JP) 1990-04-18 EP disclosed
EP-0136142-B1 THERMALLY DEVELOPABLE, LIGHT-SENSITIVE MATERIAL KONICA CORPORATION (JP) 1990-04-11 EP disclosed
US-4840882-A CONTAINING A VINYL SULFONYL HARDENER KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) 1989-06-20 US disclosed
EP-0174135-B1 HEAT-DEVELOPABLE COLOR LIGHT-SENSITIVE MATERIAL KONICA CORPORATION (JP) 1989-04-26 EP disclosed
US-4770981-A MULTILAYER, DIFFUSION TRANSFER MATERIAL HAVING SPECIFIC BINDER CONCENTRATION; ANTIFOGGING AGENTS; COLOR SEPARATION; PHOTOTHERMOGRAPHY; DRY TREATMENT KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) 1988-09-13 US disclosed
US-4584267-A SILVER HALIDE, SILVER SALT, REDUCING AGENT, AND BINDER OF GELATIN OR DERIVATIVE AND POLYVINYL ALCOHOL KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) 1986-04-22 US disclosed
EP-0174135-A2 Heat-developable color light-sensitive material KONICA CORPORATION (JP) 1986-03-12 EP disclosed
EP-0157639-A2 Heat-developable multilayered color photo-sensitive material KONICA CORPORATION (JP) 1985-10-09 EP disclosed
US-4543309-A BENZOTRIAZOLE SILVER SALT, REDUCING AGENT, BINDER, AMINO-MERCAPTO TRIAZOLE KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) 1985-09-24 US disclosed
EP-0144087-A2 Heat-developable color light-sensitive material KONICA CORPORATION (JP) 1985-06-12 EP disclosed
EP-0136142-A2 Thermally developable, light-sensitive material KONICA CORPORATION (JP) 1985-04-03 EP disclosed