Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Silver. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | CASP1 | P29466 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | TLR9 | Q9NR96 | 2/20 | 0.36 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6052025 | 0.89 | ALDH1A1 (0.44) | ALDH1A1NPSR1HPGDKDM4EMEN1 | |
| SCHEMBL9167942 | 0.88 | ALDH1A1 (0.43) | ALDH1A1NPSR1HPGDKDM4EMEN1 | |
| SCHEMBL10626863 | 0.85 | ALDH1A1 (0.41) | ALDH1A1NPSR1HPGDKDM4EMEN1 | |
| Silver SCHEMBL9166268 | 0.82 | ALDH1A1 (0.44) | ALDH1A1NPSR1HPGDKDM4EMEN1 | |
| Silver SCHEMBL9173250 | 0.82 | PKM (0.38) | ALDH1A1NPSR1KMT2AHSD17B10GAA | |
| SCHEMBL6051990 | 0.81 | ALDH1A1 (0.47) | ALDH1A1NPSR1HPGDKDM4EMEN1 | |
| SCHEMBL9638029 | 0.80 | ALDH1A1 (0.46) | ALDH1A1NPSR1HPGDKDM4EMEN1 | |
| SCHEMBL6051986 | 0.79 | ALDH1A1 (0.46) | ALDH1A1NPSR1HPGDKDM4EMEN1 | |
| SCHEMBL9166266 | 0.78 | ALDH1A1 (0.45) | ALDH1A1NPSR1HPGDKDM4EMEN1 | |
| SCHEMBL11018140 | 0.77 | USP2 (0.46) | ALDH1A1NPSR1HPGDKDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0144087-B2 | Heat-developable color light-sensitive material | KONISHIROKU PHOTO IND (JP) | 1995-05-24 | — | — | EP | disclosed |
| EP-0144087-B1 | HEAT-DEVELOPABLE COLOR LIGHT-SENSITIVE MATERIAL | KONICA CORPORATION (JP) | 1990-04-18 | — | — | EP | disclosed |
| EP-0136142-B1 | THERMALLY DEVELOPABLE, LIGHT-SENSITIVE MATERIAL | KONICA CORPORATION (JP) | 1990-04-11 | — | — | EP | disclosed |
| US-4840882-A | CONTAINING A VINYL SULFONYL HARDENER | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1989-06-20 | — | — | US | disclosed |
| US-4584267-A | SILVER HALIDE, SILVER SALT, REDUCING AGENT, AND BINDER OF GELATIN OR DERIVATIVE AND POLYVINYL ALCOHOL | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1986-04-22 | — | — | US | disclosed |
| EP-0157639-A2 | Heat-developable multilayered color photo-sensitive material | KONICA CORPORATION (JP) | 1985-10-09 | — | — | EP | disclosed |
| US-4543309-A | BENZOTRIAZOLE SILVER SALT, REDUCING AGENT, BINDER, AMINO-MERCAPTO TRIAZOLE | KONISHIROKU PHOTO INDUSTRY CO., LTD. (JP) | 1985-09-24 | — | — | US | disclosed |
| EP-0144087-A2 | Heat-developable color light-sensitive material | KONICA CORPORATION (JP) | 1985-06-12 | — | — | EP | disclosed |
| EP-0136142-A2 | Thermally developable, light-sensitive material | KONICA CORPORATION (JP) | 1985-04-03 | — | — | EP | disclosed |