Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 5/20 | 1.00 |
| ▸ | HTR1A | P08908 | 2/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 2/20 | 1.00 |
| ▸ | ADRA1D | P25100 | 1/20 | 1.00 |
| ▸ | ADRA1B | P35368 | 1/20 | 1.00 |
| ▸ | DRD4 | P21917 | 3/20 | 0.74 |
| ▸ | DRD2 | P14416 | 2/20 | 0.74 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9249152 | 0.85 | SIGMAR1 (1.00) | SIGMAR1HTR1AADRA1AADRA1DADRA1B | |
| SCHEMBL9247478 | 0.85 | SIGMAR1 (1.00) | SIGMAR1HTR1AADRA1AADRA1DADRA1B | |
| SCHEMBL9250389 | 0.82 | SIGMAR1 (0.85) | SIGMAR1HTR1AADRA1ADRD4DRD2 | |
| SCHEMBL9251051 | 0.80 | SIGMAR1 (1.00) | SIGMAR1HTR1AADRA1AADRA1DADRA1B | |
| SCHEMBL8011694 | 0.80 | SIGMAR1 (0.72) | SIGMAR1HTR1AADRA1AADRA1DADRA1B | |
| SCHEMBL8000332 | 0.80 | SIGMAR1 (0.72) | SIGMAR1HTR1AADRA1ADRD4DRD2 | |
| SCHEMBL466974 | 0.79 | SIGMAR1 (1.00) | SIGMAR1HTR1A | |
| SCHEMBL31060454 | 0.79 | SIGMAR1 (1.00) | SIGMAR1HTR1A | |
| SCHEMBL9248916 | 0.79 | SIGMAR1 (0.65) | SIGMAR1HTR1AADRA1AADRA1DADRA1B | |
| SCHEMBL8021562 | 0.79 | SIGMAR1 (0.70) | SIGMAR1HTR1AADRA1ADRD4DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0647222-A1 | N(HETERO)-ARYL-N(HETERO)-TETRALIN-ALKYL-PIPERAZINE HAVING SEROTONINERGIC, DOPAMINERGIC AND ADRENERGIC ACTIVITY | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-04-12 | — | — | EP | claimed |
| WO-1994000441-A1 | N(HETERO)-ARYL-N(HETERO)-TETRALIN-ALKYL-PIPERAZINE HAVING SEROTONINERGIC, DOPAMINERGIC AND ADRENERGIC ACTIVITY | FARMITALIA CARLO ERBA S.R.L. (IT) | 1994-01-06 | — | — | WO | claimed |
| EP-0647222-A1 | N(HETERO)-ARYL-N(HETERO)-TETRALIN-ALKYL-PIPERAZINE HAVING SEROTONINERGIC, DOPAMINERGIC AND ADRENERGIC ACTIVITY | PHARMACIA & UPJOHN S.p.A. (IT) | 1995-04-12 | — | — | EP | disclosed |
| WO-1994000441-A1 | N(HETERO)-ARYL-N(HETERO)-TETRALIN-ALKYL-PIPERAZINE HAVING SEROTONINERGIC, DOPAMINERGIC AND ADRENERGIC ACTIVITY | FARMITALIA CARLO ERBA S.R.L. (IT) | 1994-01-06 | — | — | WO | disclosed |