Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPAS1 | Q99814 | 5/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | VEGFA | P15692 | 2/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 4/20 | 0.41 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.40 |
| ▸ | FNTA | P49354 | 1/20 | 0.40 |
| ▸ | FNTB | P49356 | 1/20 | 0.40 |
| ▸ | PGGT1B | P53609 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7075626 | 0.91 | SMN1; SMN2 (0.41) | EPAS1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8379001 | 0.88 | PDE4A (0.54) | EPAS1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5787364 | 0.87 | PDE4A (0.49) | EPAS1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2532878 | 0.87 | CYP19A1 (0.51) | PDE4APDE4BPDE4CPDE4DAR | |
| SCHEMBL27839327 | 0.86 | PDE4A (0.53) | EPAS1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL10923033 | 0.84 | PDE4A (0.55) | EPAS1PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL23087866 | 0.84 | GRM5 (0.46) | EPAS1PDE4APDE4BPDE4CPDE4D | |
| Water SCHEMBL29061097 | 0.82 | PGR (0.55) | PDE4APDE4BPDE4CPDE4DSLC6A2 | |
| SCHEMBL30358273 | 0.82 | PGR (0.55) | PDE4APDE4BPDE4CPDE4DSLC6A2 | |
| SCHEMBL7069974 | 0.82 | PDE4A (0.50) | EPAS1PDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0649413-A1 | URACIL DERIVATIVES AS ENZYME INHIBITORS | THE WELLCOME FOUNDATION LIMITED (GB) | 1995-04-26 | — | — | EP | disclosed |
| WO-1994001414-A1 | URACIL DERIVATIVES AS ENZYME INHIBITORS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-01-20 | — | — | WO | disclosed |