Water

Water

SCHEMBL29061097

N#Cc1cccc(Oc2ccccc2)c1.O

nearest known ligand 0.55

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ABCC9ABL1ACEACHEACVR1ADORA1ADORA2AADORA2BADORA3ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALOX5ATP4AATP4BBCRBTKCACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGCRBNCUL4ACXCR1CXCR2DDB1DDCDHFRDPP4DRD2DRD3DRD4EGFRERBB2ERBB4ESR1ESR2FDPSFKBP1AFLT1FLT3FLT4GARTGHSRGRIA1GRIA2GRIA3GRIA4GRIK1GRIK2GRIK3GRIK4GRIK5GRIN2AGSK3AGSK3BHDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IDH1IDH2IMPA1ITGA2BITGB3JAK1JAK2JAK3KCNJ11KCNK3KCNK9KDRKITMEN1METMMP1MMP13MMP7MMP8NANOD2NS5bODC1OPG057OPRD1OPRK1OPRM1PPARP1PARP2PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDGFRBPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PKLRPPARDPPATPTGS1PTGS2RBX1ROCK1ROCK2RRM1RRM2RRM2BSCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC10A2SLC5A2SLC6A2SLC6A3SLC6A4SLC9A3SYKTACR1THRATHRBTOP1TUBA1ATUBA1BTUBA1CTUBA3CTUBA3ETUBA4ATUBBTUBB1TUBB2ATUBB2BTUBB3TUBB4ATUBB4BTUBB6TUBB8TYK2TYMSVDRampCblablaT-3blaT-4blaT-5blaT-6blaUOE-1dacAdacBdacCfolAfolPftsIgyrAgyrBileSmecAmrcAmrcBmrdAparCparEpbp2pbp4pbpApbpFrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUthyAykgMykgO

The experimentally established mechanism targets of Water. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PDE4A known ✓ P27815 1/20 0.50
PDE4B known ✓ Q07343 1/20 0.50
PDE4C known ✓ Q08493 1/20 0.50
PDE4D known ✓ Q08499 1/20 0.50
MEN1 known ✓ O00255 1/20 0.47
ALOX5 known ✓ P09917 2/20 0.46
SLC6A2 known ✓ P23975 2/20 0.45
SLC6A4 known ✓ P31645 2/20 0.45
SLC6A3 known ✓ Q01959 1/20 0.45
HDAC8 known ✓ Q9BY41 1/20 0.44
PGR P06401 1/20 0.55
TSHR P16473 3/20 0.52
LTA4H P09960 1/20 0.50
MAOB P27338 1/20 0.50
AKR1C3 P42330 1/20 0.50
SLK Q9H2G2 1/20 0.48
ALDH1A1 P00352 1/20 0.47
LMNA P02545 1/20 0.47
GAA P10253 1/20 0.47
MAPT P10636 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30358273 1.00 PGR (0.55) PGRTSHRLTA4HMAOBPDE4A
SCHEMBL7186441 1.00 PGR (0.55) PGRTSHRLTA4HMAOBPDE4A
SCHEMBL10923033 0.94 PDE4A (0.55) PGRPDE4APDE4BPDE4CPDE4D
SCHEMBL8379001 0.94 PDE4A (0.54) PGRTSHRPDE4APDE4BPDE4C
SCHEMBL27839327 0.91 PDE4A (0.53) PGRTSHRPDE4APDE4BPDE4C
SCHEMBL7070717 0.90 MEN1 (0.50) PGRTSHRLTA4HMAOBPDE4A
SCHEMBL7072557 0.88 PDE4A (0.50) PGRTSHRPDE4APDE4BPDE4C
SCHEMBL7069974 0.88 PDE4A (0.50) PGRTSHRPDE4APDE4BPDE4C
Diphenylether SCHEMBL4188767 0.87 TSHR (0.70) PGRTSHRLTA4HMAOBMEN1
SCHEMBL920404 0.86 PDE4A (0.47) PGRPDE4APDE4BPDE4CPDE4D

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106918705-B Test paper for detecting fenpropathrin and application thereof 贵州勤邦食品安全科学技术有限公司 2023-06-13 CN claimed
CN-106918705-B Test paper for detecting fenpropathrin and application thereof 贵州勤邦食品安全科学技术有限公司 2023-06-13 CN disclosed