Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 2/20 | 0.81 |
| ▸ | BLM | P54132 | 1/20 | 0.81 |
| ▸ | CNR2 | P34972 | 8/20 | 0.43 |
| ▸ | CNR1 | P21554 | 7/20 | 0.43 |
| ▸ | ESR1 | P03372 | 1/20 | 0.43 |
| ▸ | PLA2G4B | P0C869 | 3/20 | 0.42 |
| ▸ | THRB | P10828 | 2/20 | 0.42 |
| ▸ | THRA | P10827 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9170511 | 1.00 | PLA2G2A (0.81) | PLA2G2ABLMCNR2CNR1ESR1 | |
| SCHEMBL9172069 | 0.98 | PLA2G2A (0.81) | PLA2G2ABLMCNR2CNR1ESR1 | |
| SCHEMBL9172169 | 0.94 | PLA2G2A (0.68) | PLA2G2ABLMESR1 | |
| SCHEMBL9173673 | 0.94 | PLA2G2A (0.68) | PLA2G2ABLMESR1 | |
| SCHEMBL9171087 | 0.90 | PLA2G2A (0.81) | PLA2G2ABLMCNR2CNR1 | |
| SCHEMBL9169893 | 0.90 | PLA2G2A (0.89) | PLA2G2ABLMCNR2CNR1ESR1 | |
| SCHEMBL9162996 | 0.90 | PLA2G2A (1.00) | PLA2G2ABLMCNR2CNR1PLA2G4B | |
| SCHEMBL9168811 | 0.90 | PLA2G2A (1.00) | PLA2G2ABLMCNR2CNR1PLA2G4B | |
| SCHEMBL9173041 | 0.90 | PLA2G2A (1.00) | PLA2G2ABLMCNR2CNR1PLA2G4B | |
| SCHEMBL9171657 | 0.90 | PLA2G2A (1.00) | PLA2G2ABLMCNR2CNR1PLA2G4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5446189-A | Diester intermediates for diacid enzyme inhibitor | HOFFMANN-LA ROCHE INC. (US) | 1995-08-29 | — | — | US | disclosed |
| US-5324747-A | Treatment of inflammatory diseases | HOFFMANN-LA ROCHE INC. (US) | 1994-06-28 | — | — | US | disclosed |
| EP-0579066-A2 | N-substituted anilines | F. HOFFMANN-LA ROCHE AG (CH) | 1994-01-19 | — | — | EP | disclosed |