Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.68 |
| ▸ | BLM | P54132 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PAM | P19021 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR1B | P28222 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 6/20 | 0.40 |
| ▸ | PPARD | Q03181 | 6/20 | 0.40 |
| ▸ | PPARA | Q07869 | 6/20 | 0.40 |
| ▸ | GPR84 | Q9NQS5 | 5/20 | 0.40 |
| ▸ | HDAC11 | Q96DB2 | 5/20 | 0.40 |
| ▸ | TSHR | P16473 | 4/20 | 0.40 |
| ▸ | TLR2 | O60603 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9172169 | 1.00 | PLA2G2A (0.68) | PLA2G2ABLMKMT2ASMN1; SMN2PAM | |
| SCHEMBL9170511 | 0.94 | PLA2G2A (0.81) | PLA2G2ABLMESR1 | |
| SCHEMBL9166827 | 0.94 | PLA2G2A (0.81) | PLA2G2ABLMESR1 | |
| SCHEMBL9172069 | 0.91 | PLA2G2A (0.81) | PLA2G2ABLMTSHRESR1 | |
| SCHEMBL14060909 | 0.83 | KMT2A (0.55) | PLA2G2AKMT2ASMN1; SMN2PAMNPC1 | |
| SCHEMBL14060987 | 0.83 | KMT2A (0.55) | PLA2G2AKMT2ASMN1; SMN2PAMNPC1 | |
| SCHEMBL9171087 | 0.83 | PLA2G2A (0.81) | PLA2G2ABLMPPARGPPARA | |
| SCHEMBL9169893 | 0.82 | PLA2G2A (0.89) | PLA2G2ABLMKMT2AALDH1A1TDP1 | |
| SCHEMBL9173041 | 0.81 | PLA2G2A (1.00) | PLA2G2ABLMTSHR | |
| SCHEMBL9168811 | 0.81 | PLA2G2A (1.00) | PLA2G2ABLMTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5446189-A | Diester intermediates for diacid enzyme inhibitor | HOFFMANN-LA ROCHE INC. (US) | 1995-08-29 | — | — | US | disclosed |
| US-5324747-A | Treatment of inflammatory diseases | HOFFMANN-LA ROCHE INC. (US) | 1994-06-28 | — | — | US | disclosed |
| EP-0579066-A2 | N-substituted anilines | F. HOFFMANN-LA ROCHE AG (CH) | 1994-01-19 | — | — | EP | disclosed |