Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CASP6 | P55212 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9169041 | 0.91 | PLA2G2A (0.59) | PLA2G2ABLMMTNR1AMTNR1BL3MBTL1 | |
| SCHEMBL9172120 | 0.90 | PLA2G2A (0.63) | PLA2G2ABLMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL9169252 | 0.90 | PLA2G2A (0.67) | PLA2G2ABLMSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL9163819 | 0.89 | PLA2G2A (0.50) | PLA2G2ABLMKDM4EMEN1KMT2A | |
| SCHEMBL9417579 | 0.87 | POLB (0.50) | PLA2G2ABLMSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL9169183 | 0.84 | PLA2G2A (0.51) | PLA2G2ABLMMTNR1AMTNR1BL3MBTL1 | |
| SCHEMBL9166116 | 0.83 | PLA2G2A (0.63) | PLA2G2ABLMSMN1; SMN2MEN1KMT2A | |
| SCHEMBL9168532 | 0.81 | PLA2G2A (0.74) | PLA2G2ABLMMEN1KMT2AALDH1A1 | |
| SCHEMBL9165405 | 0.80 | PLA2G2A (0.82) | PLA2G2ABLMSMN1; SMN2KDM4EMEN1 | |
| SCHEMBL9170198 | 0.80 | PLA2G2A (0.82) | PLA2G2ABLMSMN1; SMN2KDM4EMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5446189-A | Diester intermediates for diacid enzyme inhibitor | HOFFMANN-LA ROCHE INC. (US) | 1995-08-29 | — | — | US | disclosed |
| US-5324747-A | Treatment of inflammatory diseases | HOFFMANN-LA ROCHE INC. (US) | 1994-06-28 | — | — | US | disclosed |
| EP-0579066-A2 | N-substituted anilines | F. HOFFMANN-LA ROCHE AG (CH) | 1994-01-19 | — | — | EP | disclosed |