Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | PGK1 | P00558 | 8/20 | 0.44 |
| ▸ | PGK2 | P07205 | 8/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.32 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.32 |
| ▸ | PTPRB | P23467 | 2/20 | 0.32 |
| ▸ | TYMS | P04818 | 1/20 | 0.32 |
| ▸ | ACP3 | P15309 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11121515 | 0.81 | PGK1 (0.52) | SMN1; SMN2PGK1PGK2KDM4EMMP2 | |
| SCHEMBL11307755 | 0.72 | SMN1; SMN2 (1.00) | SMN1; SMN2PGK1PGK2MAPK1HSD17B10 | |
| SCHEMBL13512948 | 0.71 | PGK1 (0.44) | SMN1; SMN2PGK1PGK2KDM4EMMP2 | |
| SCHEMBL11320696 | 0.71 | PGK1 (0.62) | SMN1; SMN2PGK1PGK2KDM4EMMP2 | |
| SCHEMBL13742442 | 0.69 | PGK1 (0.60) | SMN1; SMN2PGK1PGK2KDM4EMMP2 | |
| SCHEMBL3206776 | 0.69 | PGK1 (0.43) | SMN1; SMN2PGK1PGK2KDM4EMMP2 | |
| SCHEMBL3219000 | 0.69 | PGK1 (0.43) | SMN1; SMN2PGK1PGK2KDM4EMMP2 | |
| SCHEMBL6571879 | 0.69 | PGK1 (0.60) | SMN1; SMN2PGK1PGK2KDM4EMMP2 | |
| SCHEMBL11452448 | 0.69 | PGK1 (0.48) | SMN1; SMN2PGK1PGK2KDM4EMMP2 | |
| SCHEMBL6519625 | 0.69 | PGK1 (0.48) | SMN1; SMN2PGK1PGK2KDM4EMMP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0561948-B1 | PHOSPHONIC ACID DERIVATIVES USEFUL AS ANTIINFLAMMATORY AGENTS | UPJOHN CO (US) | 1995-04-05 | — | — | EP | claimed |
| EP-0561948-B1 | PHOSPHONIC ACID DERIVATIVES USEFUL AS ANTIINFLAMMATORY AGENTS | UPJOHN CO (US) | 1995-04-05 | — | — | EP | disclosed |
| EP-0622373-A1 | Phosphonic acid derivatives useful as anti-inflammatory agents | THE UPJOHN COMPANY (US) | 1994-11-02 | — | — | EP | disclosed |
| US-5360797-A | Bisphosphonic acid derivatives useful as anti-arthritic agents | THE UPJOHN COMPANY (US) | 1994-11-01 | — | — | US | disclosed |
| US-5298498-A | Antiarthritic agents | THE UPJOHN COMPANY (US) | 1994-03-29 | — | — | US | disclosed |
| EP-0561948-A1 | PHOSPHONIC ACID DERIVATIVES USEFUL AS ANTIINFLAMMATORY AGENTS. | UPJOHN CO (US) | 1993-09-29 | — | — | EP | disclosed |
| WO-1992010504-A2 | PHOSPHONIC ACID DERIVATIVES USEFUL AS ANTIINFLAMMATORY AGENTS | THE UPJOHN COMPANY (US) | 1992-06-25 | — | — | WO | disclosed |