Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 2/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.49 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.48 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.48 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | RARB | P10826 | 3/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL203212 | 1.00 | PLA2G2A (0.60) | PLA2G2ATSHRTP53SMPD1PLA2G4B | |
| SCHEMBL5086980 | 0.91 | PLA2G2A (0.73) | PLA2G2ATSHRTP53SMPD1PLA2G4B | |
| SCHEMBL11695455 | 0.91 | PLA2G2A (0.73) | PLA2G2ATSHRTP53SMPD1PLA2G4B | |
| SCHEMBL14763514 | 0.91 | PLA2G2A (0.73) | PLA2G2ATSHRTP53SMPD1PLA2G4B | |
| Hydrochloric Acid SCHEMBL5005668 | 0.89 | PLA2G2A (0.71) | PLA2G2ATSHRTP53SMPD1PLA2G4B | |
| SCHEMBL9168136 | 0.85 | PLA2G2A (0.57) | PLA2G2ATSHRTP53SMPD1PLA2G4B | |
| SCHEMBL17414620 | 0.84 | PLA2G2A (0.62) | PLA2G2ATSHRTP53PLA2G4BBLM | |
| SCHEMBL15977059 | 0.84 | PLA2G2A (0.57) | PLA2G2ATSHRTP53PLA2G4BNPC1 | |
| SCHEMBL201440 | 0.84 | PLA2G2A (0.59) | PLA2G2ATSHRTP53SMPD1PLA2G4B | |
| SCHEMBL12709821 | 0.82 | TSHR (0.68) | PLA2G2ATSHRTP53PLA2G4BBLM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5446189-A | Diester intermediates for diacid enzyme inhibitor | HOFFMANN-LA ROCHE INC. (US) | 1995-08-29 | — | — | US | disclosed |
| US-5324747-A | Treatment of inflammatory diseases | HOFFMANN-LA ROCHE INC. (US) | 1994-06-28 | — | — | US | disclosed |
| EP-0579066-A2 | N-substituted anilines | F. HOFFMANN-LA ROCHE AG (CH) | 1994-01-19 | — | — | EP | disclosed |