Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 8/20 | 0.58 |
| ▸ | BCHE | P06276 | 5/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.58 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.58 |
| ▸ | TSHR | P16473 | 4/20 | 0.58 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.58 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.58 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.58 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.58 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.58 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.58 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.58 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.58 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.58 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9216711 | 0.85 | ACHE (0.62) | ACHEBCHEALDH1A1HSD17B10TSHR | |
| SCHEMBL4502500 | 0.85 | ACHE (0.62) | ACHEBCHEALDH1A1HSD17B10TSHR | |
| SCHEMBL9737406 | 0.83 | ACHE (0.68) | ACHEBCHEALDH1A1HSD17B10TSHR | |
| SCHEMBL9735057 | 0.83 | ACHE (0.68) | ACHEBCHEALDH1A1HSD17B10TSHR | |
| SCHEMBL9738344 | 0.77 | ACHE (0.69) | ACHEBCHEALDH1A1HSD17B10TSHR | |
| SCHEMBL9168843 | 0.74 | KMT2A (0.61) | ACHELMNASMN1; SMN2GAATP53 | |
| SCHEMBL9211865 | 0.74 | ACHE (0.62) | ACHEBCHEGRIN1GRIN2A | |
| SCHEMBL9171949 | 0.74 | ACHE (0.42) | ACHEBCHECHRM1GRIN1GRIN2A | |
| Tacrine SCHEMBL2828 | 0.74 | ACHE (1.00) | ACHEBCHEALDH1A1HSD17B10TSHR | |
| SCHEMBL5047992 | 0.74 | ACHE (1.00) | ACHEBCHEALDH1A1HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0287977-B1 | Fused heteroalkylene quinolinamines, a process and intermediates for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1994-06-29 | — | — | EP | claimed |
| US-5112830-A | Cognition Activators | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1992-05-12 | — | — | US | claimed |
| EP-0287977-A2 | Fused heteroalkylene quinolinamines, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-10-26 | — | — | EP | claimed |
| US-5389629-A | Increase cholinergic function | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1995-02-14 | — | — | US | disclosed |
| EP-0287977-B1 | Fused heteroalkylene quinolinamines, a process and intermediates for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1994-06-29 | — | — | EP | disclosed |
| US-5208330-A | Cognition activators | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-05-04 | — | — | US | disclosed |
| US-5206387-A | Chemical intermediates for memory enhancing drugs | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-04-27 | — | — | US | disclosed |
| US-5112830-A | Cognition Activators | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1992-05-12 | — | — | US | disclosed |
| US-5002955-A | Pyrroloquinolines for enhancement of memory | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-03-26 | — | — | US | disclosed |
| US-4843079-A | ALZHEIMER*S DISEASE | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-06-27 | — | — | US | disclosed |
| EP-0287977-A2 | Fused heteroalkylene quinolinamines, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-10-26 | — | — | EP | disclosed |
| EP-0268871-A1 | Quinoline derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1988-06-01 | — | — | EP | disclosed |