Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 16/20 | 1.00 |
| ▸ | BCHE | P06276 | 15/20 | 1.00 |
| ▸ | GRIN1 | Q05586 | 10/20 | 0.93 |
| ▸ | GRIN2A | Q12879 | 10/20 | 0.93 |
| ▸ | TSHR | P16473 | 3/20 | 0.93 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.93 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.93 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.93 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.93 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.93 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.93 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.93 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.93 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.93 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.93 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.93 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.93 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.93 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.93 |
| ▸ | APP | P05067 | 1/20 | 0.93 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30063279 | 1.00 | ACHE (1.00) | ACHEBCHEGRIN1GRIN2ATSHR | |
| Tacrine SCHEMBL7714835 | 0.96 | ACHE (1.00) | ACHEBCHEGRIN1GRIN2ATSHR | |
| Tacrine SCHEMBL2828 | 0.96 | ACHE (1.00) | ACHEBCHEGRIN1GRIN2ATSHR | |
| Tacrine SCHEMBL29681895 | 0.96 | ACHE (1.00) | ACHEBCHEGRIN1GRIN2ATSHR | |
| Tacrine SCHEMBL29594645 | 0.96 | ACHE (1.00) | ACHEBCHEGRIN1GRIN2ATSHR | |
| Tacrine SCHEMBL14236722 | 0.95 | ACHE (0.97) | ACHEBCHEGRIN1GRIN2ATSHR | |
| SCHEMBL12043403 | 0.95 | ACHE (1.00) | ACHEBCHEGRIN1GRIN2ATSHR | |
| Tacrine SCHEMBL9407893 | 0.95 | CYP1A2 (0.97) | ACHEBCHEGRIN1GRIN2ATSHR | |
| Tacrine SCHEMBL1044163 | 0.95 | ACHE (1.00) | ACHEBCHEGRIN1GRIN2ATSHR | |
| Tacrine SCHEMBL8000475 | 0.95 | ACHE (0.97) | ACHEBCHEGRIN1GRIN2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 45 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170354655-A1 | TLR INHIBITOR AND BRUTON'S TYROSINE KINASE INHIBITOR COMBINATIONS | PHARMACYCLICS LLC | 2017-12-14 | — | — | US | claimed |
| EP-3220912-A1 | TLR INHIBITOR AND BRUTON'S TYROSINE KINASE INHIBITOR COMBINATIONS | Pharmacyclics LLC (US) | 2017-09-27 | — | — | EP | claimed |
| WO-2016081460-A1 | TLR INHIBITOR AND BRUTON'S TYROSINE KINASE INHIBITOR COMBINATIONS | PHARMACYCLICS LLC (US) | 2016-05-26 | — | — | WO | claimed |
| US-20220296628-A1 | RNA COMBINATIONS AND COMPOSITIONS WITH DECREASED IMMUNOSTIMULATORY PROPERTIES | CUREVAC AG (DE) | 2022-09-22 | — | — | US | disclosed |
| EP-4013880-A1 | RNA COMBINATIONS AND COMPOSITIONS WITH DECREASED IMMUNOSTIMULATORY PROPERTIES | CureVac AG (DE) | 2022-06-22 | — | — | EP | disclosed |
| CN-114502204-A | RNA combinations and compositions with reduced immunostimulatory properties | 库尔维科公司 | 2022-05-13 | — | — | CN | disclosed |
| US-11254651-B2 | Histone methyltransferase inhibitors | GLOBAL BLOOD THERAPEUTICS, INC. (US) | 2022-02-22 | — | — | US | disclosed |
| WO-2021028439-A1 | RNA COMBINATIONS AND COMPOSITIONS WITH DECREASED IMMUNOSTIMULATORY PROPERTIES | CUREVAC AG (DE) | 2021-02-18 | — | — | WO | disclosed |
| US-20190298841-A1 | Nucleic Acid Complexes | PROCARTA BIOSYSTEMS LTD (GB) | 2019-10-03 | — | — | US | disclosed |
| US-10350299-B2 | Nucleic acid complexes | PROCARTA BIOSYSTEMS LTD. (GB) | 2019-07-16 | — | — | US | disclosed |
| US-20190047981-A1 | HISTONE METHYLTRANSFERASE INHIBITORS | GLOBAL BLOOD THERAPEUTICS, INC. | 2019-02-14 | — | — | US | disclosed |
| US-20070232622-A1 | Small molecule toll-like receptor (TLR) antagonists | COLEY PHARMACEUTICAL GMBH (DE) | 2007-10-04 | — | — | US | disclosed |
| US-20070232622-A1 | Small molecule toll-like receptor (TLR) antagonists | COLEY PHARMACEUTICAL GMBH (DE) | 2007-10-04 | — | — | US | disclosed |
| US-20070060605-A1 | Compositions and methods for inhibiting platelet activation and thrombosis | FLAUMENHAFT ROBERT C | 2007-03-15 | — | — | US | disclosed |
| US-7166612-B2 | Methods for reducing platelet activation platelet aggregaton or thrombosis | BETH ISRAEL DEACONESS MEDICAL CENTER (US) | 2007-01-23 | — | — | US | disclosed |
| US-20050119273-A1 | Small molecule toll-like receptor (TLR) antagonists | COLEY PHARMACEUTICAL GMBH (DE) | 2005-06-02 | — | — | US | disclosed |
| US-20040147540-A1 | Compositions and methods for inhibiting platelet activation and thrombosis | BETH ISRAEL DEACONESS MEDICAL CENTER | 2004-07-29 | — | — | US | disclosed |
| EP-1406621-A2 | COMPOSITIONS AND METHODS FOR INHIBITING PLATELET ACTIVATION AND THROMBOSIS | Beth Israel Deaconess Medical Center (US) | 2004-04-14 | — | — | EP | disclosed |
| WO-2003001968-A2 | COMPOSITIONS AND METHODS FOR INHIBITING PLATELET ACTIVATION AND THROMBOSIS | BETH ISRAEL DEACONESS MEDICAL CENTER (US) | 2003-01-09 | — | — | WO | disclosed |
| US-6130228-A | Polycyclic compounds | UNIVERSITY OF STRATHCLYDE (GB) | 2000-10-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (10 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070060605-A1 | Compositions and methods for inhibiting platelet activation and thrombosis | PLA2G7, PLTP, PLAAT2 | ACHE 3872/4885BCHE 4539/4885GRIN1 4341/4885 |
| US-10350299-B2 | Nucleic acid complexes | ZFR, SUB1, RELA | ACHE 4834/4885BCHE 4569/4885GRIN1 3867/4885 |
| US-20050119273-A1 | Small molecule toll-like receptor (TLR) antagonists | TLR3, TLR8, TLR7 | ACHE 4643/4885BCHE 4206/4885GRIN1 566/4885 |
| US-20070232622-A1 | Small molecule toll-like receptor (TLR) antagonists | TLR3, TLR8, TLR7 | ACHE 4643/4885BCHE 4206/4885GRIN1 566/4885 |
| US-20170354655-A1 | TLR INHIBITOR AND BRUTON'S TYROSINE KINASE INHIBITOR COMBINATIONS | BTK, TLR3, TLR9 | ACHE 4883/4885BCHE 4393/4885GRIN1 1986/4885 |
| US-20190047981-A1 | HISTONE METHYLTRANSFERASE INHIBITORS | EHMT1, EHMT2, BMI1 | ACHE 3056/4885BCHE 1184/4885GRIN1 2850/4885 |
| US-20190298841-A1 | Nucleic Acid Complexes | ZFR, SUB1, RELA | ACHE 4834/4885BCHE 4569/4885GRIN1 3867/4885 |
| US-20040147540-A1 | Compositions and methods for inhibiting platelet activation and thrombosis | PLA2G7, PLTP, PLAAT2 | ACHE 3872/4885BCHE 4539/4885GRIN1 4341/4885 |
| US-20220296628-A1 | RNA COMBINATIONS AND COMPOSITIONS WITH DECREASED IMMUNOSTIMULATORY PROPERTIES | TLR3, EIF2AK2, STING1 | ACHE 4829/4885BCHE 4715/4885GRIN1 2323/4885 |
| US-11254651-B2 | Histone methyltransferase inhibitors | EHMT1, EHMT2, BMI1 | ACHE 3056/4885BCHE 1184/4885GRIN1 2850/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.