Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 7/20 | 0.42 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.39 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.39 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.39 |
| ▸ | TNKS | O95271 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | PDE9A | O76083 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.33 |
| ▸ | CDK9 | P50750 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9170433 | 0.85 | PTPN1 (0.39) | PTPN1ADORA2ATNKSMAPTPDE9A | |
| SCHEMBL11552940 | 0.82 | ADORA2A (0.51) | PTPN1ADORA2ATNKSMAPTPDE9A | |
| SCHEMBL7012510 | 0.80 | PDE9A (0.47) | PTPN1ADORA2ATNKSMAPTPDE9A | |
| SCHEMBL9176872 | 0.78 | TNKS (0.51) | PTPN1ADORA2ATNKSMAPTALDH1A1 | |
| SCHEMBL9176674 | 0.77 | TNKS (0.40) | PTPN1ADORA2ATNKSMAPTALDH1A1 | |
| SCHEMBL11547143 | 0.74 | HNF4A (0.44) | PTPN1TNKSMAPTALDH1A1KMT2A | |
| SCHEMBL30882027 | 0.74 | CA1 (0.59) | ADORA2ATNKSMAPTPDE9AALDH1A1 | |
| SCHEMBL3867351 | 0.72 | PTPN1 (0.77) | PTPN1 | |
| SCHEMBL9175334 | 0.71 | TNKS (0.42) | PTPN1TNKSMAPTALDH1A1KMT2A | |
| SCHEMBL18920818 | 0.71 | TSHR (0.52) | PTPN1ALDH1A1LMNAHTTPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640080-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS. | SYNTEX INC (US) | 1995-03-01 | — | — | EP | disclosed |
| US-5380739-A | Angiotensin II antagonists | SYNTEX (U.S.A.) INC. (US) | 1995-01-10 | — | — | US | disclosed |
| WO-1993023391-A1 | SUBSTITUTED INDOLES AND AZAINDOLES AS ANGIOTENSIN II ANTAGONISTS | SYNTEX (U.S.A.) INC. (US) | 1993-11-25 | — | — | WO | disclosed |