Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.41 |
| ▸ | FAAH | O00519 | 17/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9417482 | 0.83 | PLA2G2A (0.43) | PLA2G2AFAAH | |
| SCHEMBL9163164 | 0.81 | MAPT (0.48) | FAAHSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL9170373 | 0.81 | FAAH (0.41) | PLA2G2AFAAHSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL9168034 | 0.78 | FAAH (0.49) | FAAHSMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL9166795 | 0.73 | PLA2G2A (0.73) | PLA2G2AALDH1A1 | |
| SCHEMBL9171916 | 0.72 | PLA2G2A (0.56) | PLA2G2A | |
| SCHEMBL11668522 | 0.69 | EPHX1 (0.59) | SMN1; SMN2ALDH1A1LMNA | |
| SCHEMBL9167882 | 0.69 | TSHR (0.53) | PLA2G2ALMNA | |
| SCHEMBL9171172 | 0.68 | FAAH (0.56) | PLA2G2AFAAH | |
| SCHEMBL9165439 | 0.68 | PLA2G2A (0.74) | PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5446189-A | Diester intermediates for diacid enzyme inhibitor | HOFFMANN-LA ROCHE INC. (US) | 1995-08-29 | — | — | US | disclosed |
| US-5324747-A | Treatment of inflammatory diseases | HOFFMANN-LA ROCHE INC. (US) | 1994-06-28 | — | — | US | disclosed |
| EP-0579066-A2 | N-substituted anilines | F. HOFFMANN-LA ROCHE AG (CH) | 1994-01-19 | — | — | EP | disclosed |