Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 2/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.37 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3683455 | 0.98 | CYP2D6 (0.44) | CYP2D6HTR2ACYP2A6SMN1; SMN2TAAR1 | |
| SCHEMBL5871483 | 0.81 | TAAR1 (0.45) | TAAR1LOXL2SIGMAR1 | |
| SCHEMBL596253 | 0.79 | HIF1A (0.39) | CYP2D6SIGMAR1ALDH1A1MAPTAPOBEC3A | |
| SCHEMBL11846749 | 0.77 | HIF1A (0.41) | CYP2D6LOXL2SIGMAR1SLC6A3ALDH1A1 | |
| SCHEMBL9935058 | 0.76 | ALDH1A1 (0.51) | CYP2D6CHRM3ALDH1A1HPGDMAPT | |
| Water SCHEMBL16291574 | 0.74 | ALDH1A1 (0.50) | CYP2D6CHRM3ALDH1A1HPGDMAPT | |
| SCHEMBL7363979 | 0.74 | SIGMAR1 (0.40) | CYP2D6SIGMAR1OPRM1CHRM3SLC6A3 | |
| SCHEMBL9935073 | 0.73 | KCNH2 (0.49) | CYP2D6CHRM3ALDH1A1HPGDMAPT | |
| SCHEMBL8129725 | 0.73 | HTR2A (0.43) | CYP2D6HTR2ACYP2A6SMN1; SMN2TAAR1 | |
| SCHEMBL1831948 | 0.72 | HIF1A (0.41) | CYP2D6LOXL2SIGMAR1SLC6A3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2252149-B1 | A METHOD FOR THE PREPARATION OF FENTANYL | DIRECTOR GENERAL DEFENCE RES & DEV ORG (IN) | 2013-11-20 | — | — | EP | disclosed |
| US-8399677-B2 | Method for the preparation of fentanyl | DEFENCE RESEARCH & DEVELOPMENT ORGANISATION (IN) | 2013-03-19 | — | — | US | disclosed |
| US-20110021781-A1 | Method for the Preparation of Fentanyl | Director General Defence Research & Development Organization, Ministry of Defence (IN) | 2011-01-27 | — | — | US | disclosed |
| EP-2252149-A2 | A METHOD FOR THE PREPARATION OF FENTANYL | Director General, Defence Research & Development Organisation (IN) | 2010-11-24 | — | — | EP | disclosed |
| WO-2009116084-A2 | A METHOD FOR THE PREPARATION OF FENTANYL | DIRECTOR GENERAL, DEFENCE RESEARCH & DEVELOPMENT ORGANISATION, MINISTRY OF DEFENCE (IN) | 2009-09-24 | — | — | WO | disclosed |
| US-20080132540-A1 | NON-PEPTIDIC NPY Y2 RECEPTOR INHIBITORS | CARRUTHERS NICHOLAS I | 2008-06-05 | — | — | US | disclosed |
| US-7317025-B2 | Non-peptidic NPY Y2 receptor inhibitors | JOHNSON & JOHNSON PHARMACEUTICAL RESEARCH & DEVELOPMENT, LLC (US) | 2008-01-08 | — | — | US | disclosed |
| WO-2005030754-A1 | INDOLE OR QUINOLINE DERIVATIVES AS NON-PEPTICID NPY Y2 RECEPTOR INHIBITORS USEFUL FOR THE TREATMENT OF ANXIOLYTIC AND DEPRESSIVE DISORDERS AND OBESITY | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-04-07 | — | — | WO | disclosed |
| US-20050070534-A1 | Non-peptidic NPY Y2 receptor inhibitors | JANSSEN PHARMACEUTICA, N.V. (BE) | 2005-03-31 | — | — | US | disclosed |
| WO-1999032488-A1 | METHOD FOR PREPARING A HYDANTOIN DERIVATIVE SUBSTITUTED IN POSITION 5, METHOD FOR PREPARING AN α-AMINO ACID ALKALINE SALT FROM SAID HYDANTOIN DERIVATIVE AND METHOD FOR ESTERIFYING CYCLIC α-AMINO ACIDS | SERANALIS (FR) | 1999-07-01 | — | — | WO | disclosed |
| US-4900738-A | OPIOID ANTAGONISTS; REDUCE SIDE EFFECTS | BOC, INC. (US) | 1990-02-13 | — | — | US | disclosed |
| US-4791112-A | ANALGESICS, NAQRCOTIC ANTAGONISTS | THE BOC GROUP, INC. (US) | 1988-12-13 | — | — | US | disclosed |
| US-4481360-A | 4H-1,2,4-Triazol-3-yl compounds | THE UPJOHN COMPANY (US) | 1984-11-06 | — | — | US | disclosed |
| US-4225731-A | Process for the preparation of trifluoromethylphenols | BAYER AKTIENGESELLSCHAFT (DE) | 1980-09-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132540-A1 | NON-PEPTIDIC NPY Y2 RECEPTOR INHIBITORS | NPY2R, NPY1R, NPY5R | CYP2D6 4313/4885HTR2A 91/4885CYP2A6 3804/4885 |
| US-20050070534-A1 | Non-peptidic NPY Y2 receptor inhibitors | NPY2R, NPY1R, NPY5R | CYP2D6 4313/4885HTR2A 91/4885CYP2A6 3804/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.