SCHEMBL9171007

SCHEMBL9171007

O=C1C=C(c2ccccc2)C(=O)N1Cc1ccccc1

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
RGS4 P49798 2/20 0.79
MGLL Q99685 2/20 0.53
GSK3A P49840 2/20 0.53
GSK3B P49841 2/20 0.53
ELANE P08246 2/20 0.52
F2 P00734 1/20 0.52
PLG P00747 1/20 0.52
CTSG P08311 1/20 0.52
CMA1 P23946 1/20 0.52
CTRC Q99895 1/20 0.52
FAAH O00519 1/20 0.51
ALDH1A1 P00352 4/20 0.49
NPSR1 Q6W5P4 2/20 0.47
GAA P10253 1/20 0.47
MAPT P10636 1/20 0.47
HPGD P15428 1/20 0.47
ALOX12 P18054 1/20 0.47
CCR6 P51684 1/20 0.47
CACNA1B Q00975 1/20 0.47
APBA1 Q02410 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28170451 0.90 RGS4 (0.67) RGS4MGLLGSK3AGSK3BELANE
SCHEMBL28976672 0.89 RGS4 (0.65) RGS4MGLLGSK3AGSK3BELANE
SCHEMBL13517162 0.89 RGS4 (1.00) RGS4MGLLGSK3AGSK3BELANE
SCHEMBL28976692 0.89 RGS4 (0.65) RGS4MGLLGSK3AGSK3BELANE
SCHEMBL29259507 0.85 RGS4 (0.60) RGS4MGLLGSK3AGSK3BALDH1A1
SCHEMBL30875783 0.85 RGS4 (0.60) RGS4MGLLGSK3AGSK3BALDH1A1
SCHEMBL28976689 0.85 RGS4 (0.60) RGS4ALDH1A1GAAMAPTMEN1
SCHEMBL30272725 0.85 RGS4 (0.60) RGS4ALDH1A1GAAMAPTMEN1
SCHEMBL28976684 0.85 RGS4 (0.60) RGS4MGLLGSK3AGSK3BELANE
SCHEMBL2644212 0.85 RGS4 (0.64) RGS4GSK3AGSK3BCMA1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5096948-A Maleimide copolymer, hindered amine stabilizer, discoloration inhibition SANKYO COMPANY, LIMITED (JP) 1992-03-17 US claimed
CN-113149968-B Compound serving as ketohexokinase inhibitor and application thereof 博济医药科技股份有限公司 2024-06-04 CN disclosed
CN-113461690-B Synthesis method of chiral 4,6-dioxooctahydropyrrolo [3,4-c ] pyrrole-1-carboxylate compound 中国科学院大连化学物理研究所 2023-03-31 CN disclosed
CN-111316986-B Application of maleimide compound as chitin synthetase inhibitor 浙江工业大学 2021-10-15 CN disclosed
CN-113149968-A Compound serving as ketohexokinase inhibitor and application thereof 广州博济医药生物技术股份有限公司 2021-07-23 CN disclosed
CN-111316986-A Application of maleimide compound as chitin synthetase inhibitor 浙江工业大学 2020-06-23 CN disclosed
EP-0407113-B1 Resistant resin compositions SANKYO CO (JP) 1995-03-29 EP disclosed
US-5096948-A Maleimide copolymer, hindered amine stabilizer, discoloration inhibition SANKYO COMPANY, LIMITED (JP) 1992-03-17 US disclosed
EP-0407113-A1 Resistant resin compositions Sankyo Company Limited (JP) 1991-01-09 EP disclosed