Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Citric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA4 | P22748 | 3/20 | 0.89 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Citric Acid SCHEMBL12988107 | 0.97 | CA4 (0.84) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL22686437 | 0.97 | CA4 (0.94) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL42945 | 0.97 | CA4 (0.94) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL29587574 | 0.97 | CA4 (0.94) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL1291555 | 0.97 | CA4 (0.94) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL23012792 | 0.94 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL21555662 | 0.94 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL362818 | 0.94 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL20668547 | 0.94 | CA4 (0.89) | CA4ALDH1A1CASP1 | |
| Citric Acid SCHEMBL1155635 | 0.94 | CA4 (0.89) | CA4ALDH1A1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0543802-B1 | Process for preparing a cerium oxide with high specific surface area | GEN MOTORS CORP (US) | 1995-03-08 | — | — | EP | disclosed |
| EP-0475490-B1 | Improved alumina-ceria catalyst washcoat | GEN MOTORS CORP (US) | 1994-01-12 | — | — | EP | disclosed |
| EP-0543802-A2 | Process for preparing a cerium oxide with high specific surface area | GENERAL MOTORS CORPORATION (US) | 1993-05-26 | — | — | EP | disclosed |
| EP-0475490-A1 | Improved alumina-ceria catalyst washcoat | GENERAL MOTORS CORPORATION (US) | 1992-03-18 | — | — | EP | disclosed |
| US-5081095-A | METHOD OF MAKING A SUPPORT CONTAINING AN ALUMINA-CERIA WASHCOAT FOR A NOBLE METAL CATALYST | GENERAL MOTORS CORPORATION (US) | 1992-01-14 | — | — | US | disclosed |
| EP-0460730-A1 | Base metal automotive exhaust catalysts with improved activity and stability | GENERAL MOTORS CORPORATION (US) | 1991-12-11 | — | — | EP | disclosed |
| US-5063193-A | Oxides of aluminum, cerium, copper, tin, chromium and manganese | GENERAL MOTORS CORPORATION (US) | 1991-11-05 | — | — | US | disclosed |