Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP9 | P14780 | 20/20 | 0.51 |
| ▸ | MMP1 | P03956 | 11/20 | 0.51 |
| ▸ | MMP3 | P08254 | 10/20 | 0.51 |
| ▸ | ADAM17 | P78536 | 9/20 | 0.51 |
| ▸ | ADAM9 | Q13443 | 9/20 | 0.51 |
| ▸ | AREG | P15514 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13545530 | 0.79 | CHEK1 (0.46) | MMP9MMP1MMP3ADAM17ADAM9 | |
| SCHEMBL12992250 | 0.79 | CHEK1 (0.46) | MMP9MMP1MMP3ADAM17ADAM9 | |
| SCHEMBL12125014 | 0.78 | NR1D1 (0.45) | MMP9MMP1MMP3ADAM17ADAM9 | |
| SCHEMBL6369530 | 0.78 | NR1D1 (0.45) | MMP9MMP1MMP3ADAM17ADAM9 | |
| SCHEMBL29177033 | 0.77 | CHEK1 (0.47) | MMP9MMP1MMP3ADAM17ADAM9 | |
| SCHEMBL28611516 | 0.75 | CHEK1 (0.45) | MMP9MMP1MMP3ADAM17ADAM9 | |
| SCHEMBL29655525 | 0.75 | CHEK1 (0.45) | MMP9MMP1MMP3ADAM17ADAM9 | |
| SCHEMBL12878828 | 0.75 | CHEK1 (0.45) | MMP9MMP1MMP3ADAM17ADAM9 | |
| SCHEMBL15704266 | 0.75 | CHEK1 (0.48) | MMP9MMP1MMP3ADAM17ADAM9 | |
| SCHEMBL15704265 | 0.75 | CHEK1 (0.48) | MMP9MMP1MMP3ADAM17ADAM9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0650360-A1 | PHOSPHONO DERIVATIVES AS ANTIINFLAMMATORY AND ANTIARTHRITIC AGENTS | THE UPJOHN COMPANY (US) | 1995-05-03 | — | — | EP | disclosed |
| WO-1994002152-A2 | PHOSPHONO DERIVATIVES AS ANTIINFLAMMATORY AND ANTIARTHRITIC AGENTS | THE UPJOHN COMPANY (US) | 1994-02-03 | — | — | WO | disclosed |