Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS | O95271 | 2/20 | 0.46 |
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.46 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.46 |
| ▸ | WNT3A | P56704 | 1/20 | 0.46 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.46 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.46 |
| ▸ | AXIN2 | Q9Y2T1 | 1/20 | 0.46 |
| ▸ | PARP3 | Q9Y6F1 | 1/20 | 0.46 |
| ▸ | ACHE | P22303 | 14/20 | 0.45 |
| ▸ | BCHE | P06276 | 9/20 | 0.43 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.43 |
| ▸ | GRIN1 | Q05586 | 6/20 | 0.41 |
| ▸ | GRIN2A | Q12879 | 6/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.37 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.37 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.37 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9163178 | 0.90 | TNKS (0.46) | TNKSPARP1TNKS2PARP2WNT3A | |
| SCHEMBL9171949 | 0.88 | ACHE (0.42) | TNKSPARP1TNKS2PARP2ACHE | |
| SCHEMBL9164979 | 0.83 | ACHE (0.66) | ACHEBCHECHRM1EPHX2GRIN1 | |
| SCHEMBL9172294 | 0.80 | ACHE (0.66) | ACHEBCHECHRM1EPHX2GRIN1 | |
| SCHEMBL4502500 | 0.76 | ACHE (0.62) | ACHEBCHECHRM1GRIN1GRIN2A | |
| SCHEMBL9167545 | 0.76 | ACHE (0.44) | ACHEBCHECHRM1EPHX2GRIN1 | |
| SCHEMBL10652434 | 0.75 | TNKS (0.47) | TNKSPARP1TNKS2PARP2WNT3A | |
| SCHEMBL10655404 | 0.73 | ACHE (0.45) | ACHEBCHECHRM1EPHX2GRIN1 | |
| SCHEMBL10351570 | 0.72 | ACHE (0.46) | ACHEBCHECHRM1EPHX2GRIN1 | |
| SCHEMBL10653389 | 0.72 | ACHE (0.66) | ACHEBCHECHRM1EPHX2GRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5112830-A | Cognition Activators | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1992-05-12 | — | — | US | claimed |
| US-5389629-A | Increase cholinergic function | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1995-02-14 | — | — | US | disclosed |
| EP-0287977-B1 | Fused heteroalkylene quinolinamines, a process and intermediates for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1994-06-29 | — | — | EP | disclosed |
| US-5208330-A | Cognition activators | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-05-04 | — | — | US | disclosed |
| US-5206387-A | Chemical intermediates for memory enhancing drugs | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1993-04-27 | — | — | US | disclosed |
| US-5112830-A | Cognition Activators | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1992-05-12 | — | — | US | disclosed |
| US-5002955-A | Pyrroloquinolines for enhancement of memory | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1991-03-26 | — | — | US | disclosed |
| US-4843079-A | ALZHEIMER*S DISEASE | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-06-27 | — | — | US | disclosed |