Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 2/20 | 0.61 |
| ▸ | BLM | P54132 | 1/20 | 0.61 |
| ▸ | PLA2G4B | P0C869 | 4/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.50 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | THRA | P10827 | 1/20 | 0.48 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.47 |
| ▸ | RARB | P10826 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9169101 | 0.90 | PLA2G2A (0.61) | PLA2G2ABLMPLA2G4BTSHRTDP1 | |
| SCHEMBL9167170 | 0.82 | PLA2G2A (0.53) | PLA2G2ABLMPLA2G4BTSHRTDP1 | |
| SCHEMBL9163152 | 0.81 | PLA2G2A (0.57) | PLA2G2ABLMPLA2G4BTSHRTP53 | |
| SCHEMBL9972488 | 0.79 | PLA2G2A (0.74) | PLA2G2ABLMPLA2G4BTSHRTP53 | |
| SCHEMBL7820620 | 0.77 | PTPN11 (0.64) | PLA2G2APLA2G4BTSHRTP53THRA | |
| SCHEMBL5492191 | 0.77 | PTPN11 (0.64) | PLA2G2APLA2G4BTSHRTP53THRA | |
| SCHEMBL9168861 | 0.77 | PLA2G2A (0.75) | PLA2G2ABLMPLA2G4BTSHRTHRA | |
| SCHEMBL28531850 | 0.77 | PLA2G2A (0.75) | PLA2G2ABLMPLA2G4BTSHRTHRA | |
| SCHEMBL9402533 | 0.77 | PLA2G2A (0.52) | PLA2G2ABLMPLA2G4BTSHRTP53 | |
| SCHEMBL9402707 | 0.77 | PLA2G2A (0.52) | PLA2G2ABLMPLA2G4BTSHRTP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5446189-A | Diester intermediates for diacid enzyme inhibitor | HOFFMANN-LA ROCHE INC. (US) | 1995-08-29 | — | — | US | disclosed |
| US-5324747-A | Treatment of inflammatory diseases | HOFFMANN-LA ROCHE INC. (US) | 1994-06-28 | — | — | US | disclosed |
| EP-0579066-A2 | N-substituted anilines | F. HOFFMANN-LA ROCHE AG (CH) | 1994-01-19 | — | — | EP | disclosed |