Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | PTPN11 | Q06124 | 8/20 | 0.51 |
| ▸ | PLA2G4B | P0C869 | 2/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.48 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.47 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.47 |
| ▸ | THRA | P10827 | 1/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9402707 | 1.00 | PLA2G2A (0.52) | PLA2G2ABLMPTPN11PLA2G4BPTPN1 | |
| SCHEMBL9402567 | 0.92 | PTPN11 (0.50) | PLA2G2ABLMPTPN11PLA2G4BPTPN1 | |
| SCHEMBL9402542 | 0.90 | PTPN11 (0.50) | PLA2G2ABLMPTPN11PLA2G4B | |
| SCHEMBL9402877 | 0.90 | PTPN11 (0.50) | PLA2G2ABLMPTPN11PLA2G4B | |
| SCHEMBL9402646 | 0.90 | PTPN11 (0.50) | PLA2G2ABLMPTPN11PLA2G4B | |
| SCHEMBL9402565 | 0.89 | PTPN11 (0.47) | PLA2G2ABLMPTPN11PLA2G4BPTPN1 | |
| SCHEMBL9402789 | 0.89 | PTPN11 (0.47) | PLA2G2ABLMPTPN11PLA2G4BPTPN1 | |
| SCHEMBL9402665 | 0.88 | PLA2G2A (0.52) | PLA2G2ABLMPTPN11PLA2G4BTP53 | |
| SCHEMBL9402699 | 0.87 | PTPN11 (0.46) | PLA2G2ABLMPTPN11PLA2G4BPTPN1 | |
| SCHEMBL9403014 | 0.87 | PTPN11 (0.46) | PLA2G2ABLMPTPN11PLA2G4BPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5298652-A | N-substituted glycines, inhibitors of phospholipase A2 | HOFFMANN-LA ROCHE INC. (US) | 1994-03-29 | — | — | US | disclosed |