Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES1 | P23141 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 2/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.34 |
| ▸ | CA1 | P00915 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 1/20 | 0.34 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 2/20 | 0.33 |
| ▸ | ITGB2 | P05107 | 1/20 | 0.33 |
| ▸ | ICAM1 | P05362 | 1/20 | 0.33 |
| ▸ | ITGAL | P20701 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2431768 | 0.90 | CES1 (0.56) | CES1ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL9170732 | 0.79 | CES1 (0.36) | CES1ALDH1A1PKMBCHEACHE | |
| SCHEMBL10369233 | 0.71 | HTR2A (0.40) | CES1ALDH1A1TSHRBCHEACHE | |
| SCHEMBL10369735 | 0.71 | CES1 (0.39) | CES1P2RX7BCHEACHENOTUM | |
| SCHEMBL9391540 | 0.70 | CES1 (0.81) | CES1ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL8768338 | 0.68 | CES1 (1.00) | CES1ALDH1A1POLBMEN1KMT2A | |
| SCHEMBL14437093 | 0.68 | ITGB2 (0.46) | ALDH1A1HTR1ANOTUMITGB2ICAM1 | |
| SCHEMBL9118563 | 0.68 | APAF1 (0.33) | APAF1 | |
| SCHEMBL9179029 | 0.67 | MAOB (0.50) | CYP3A4MAPTCYP19A1 | |
| SCHEMBL9178502 | 0.67 | CYP19A1 (0.46) | ALDH1A1MAPTCYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0310096-B1 | Novel cyclic anthranilic acid derivatives and process for their preparation | KYORIN SEIYAKU KK (JP) | 1995-04-19 | — | — | EP | disclosed |
| US-5281600-A | Antiinflammatory agents, rheumatic diseases and immunomodulators | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1994-01-25 | — | — | US | disclosed |
| US-5147874-A | Antiarthritic agents | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1992-09-15 | — | — | US | disclosed |
| EP-0147805-B1 | SPIRO-LINKED PYRROLIDINE-2,5-DIONES AND PROCESS FOR THEIR PREPARATION | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1990-10-10 | — | — | EP | disclosed |
| US-4956372-A | ANTIRHEUMATOID AND IMMUNOMODULATORS | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1990-09-11 | — | — | US | disclosed |
| EP-0310096-A2 | Novel cyclic anthranilic acid derivatives and process for their preparation | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1989-04-05 | — | — | EP | disclosed |
| US-4593092-A | Spiro-linked pyrrolidin-2,5-dione | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1986-06-03 | — | — | US | disclosed |
| EP-0147805-A2 | Spiro-linked pyrrolidine-2,5-diones and process for their preparation | KYORIN PHARMACEUTICAL CO., LTD. (JP) | 1985-07-10 | — | — | EP | disclosed |