Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | CYSLTR2 | Q9NS75 | 8/20 | 0.41 |
| ▸ | CYSLTR1 | Q9Y271 | 8/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CASP6 | P55212 | 1/20 | 0.39 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PTGES | O14684 | 1/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | PPARA | Q07869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9169470 | 0.87 | PLA2G2A (0.69) | PLA2G2ABLMCYSLTR2CYSLTR1PTPN11 | |
| SCHEMBL9172394 | 0.87 | PLA2G2A (0.69) | PLA2G2ABLMCYSLTR2CYSLTR1PTPN11 | |
| SCHEMBL9164913 | 0.87 | PLA2G2A (0.69) | PLA2G2ABLMCYSLTR2CYSLTR1PTPN11 | |
| SCHEMBL9170306 | 0.85 | PLA2G2A (0.62) | PLA2G2ABLMCYSLTR2CYSLTR1POLB | |
| SCHEMBL9168583 | 0.84 | PLA2G2A (0.64) | PLA2G2ABLMCYSLTR2CYSLTR1KEAP1 | |
| SCHEMBL9168861 | 0.74 | PLA2G2A (0.75) | PLA2G2ABLMCYSLTR2CYSLTR1PPARG | |
| SCHEMBL28531850 | 0.74 | PLA2G2A (0.75) | PLA2G2ABLMCYSLTR2CYSLTR1PPARG | |
| SCHEMBL9167727 | 0.73 | PLA2G2A (0.51) | PLA2G2ABLMPPARGPPARA | |
| SCHEMBL9168493 | 0.73 | PLA2G2A (0.44) | PLA2G2ABLMPTPN11PPARGPTGES | |
| SCHEMBL9170524 | 0.72 | PLA2G2A (0.53) | PLA2G2ABLMPTPN11PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5446189-A | Diester intermediates for diacid enzyme inhibitor | HOFFMANN-LA ROCHE INC. (US) | 1995-08-29 | — | — | US | disclosed |
| US-5324747-A | Treatment of inflammatory diseases | HOFFMANN-LA ROCHE INC. (US) | 1994-06-28 | — | — | US | disclosed |
| EP-0579066-A2 | N-substituted anilines | F. HOFFMANN-LA ROCHE AG (CH) | 1994-01-19 | — | — | EP | disclosed |