Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 1/20 | 0.64 |
| ▸ | BLM | P54132 | 1/20 | 0.64 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.47 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.46 |
| ▸ | PTPN11 | Q06124 | 3/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.46 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.46 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.46 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.46 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.46 |
| ▸ | THRA | P10827 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9170306 | 0.92 | PLA2G2A (0.62) | PLA2G2ABLMCYSLTR2CYSLTR1 | |
| SCHEMBL9167727 | 0.85 | PLA2G2A (0.51) | PLA2G2ABLM | |
| SCHEMBL9170524 | 0.84 | PLA2G2A (0.53) | PLA2G2ABLMPTPN11PTPN1PTPN6 | |
| SCHEMBL9172212 | 0.84 | PLA2G2A (0.50) | PLA2G2ABLMCYSLTR2CYSLTR1KEAP1 | |
| SCHEMBL9168493 | 0.82 | PLA2G2A (0.44) | PLA2G2ABLMALDH1A1PTPN11THRA | |
| SCHEMBL9972488 | 0.81 | PLA2G2A (0.74) | PLA2G2ABLM | |
| SCHEMBL9170650 | 0.80 | ALOX15 (0.54) | PLA2G2ABLMCYSLTR2CYSLTR1 | |
| SCHEMBL9168861 | 0.80 | PLA2G2A (0.75) | PLA2G2ABLMCYSLTR2CYSLTR1SMPD1 | |
| SCHEMBL28531850 | 0.80 | PLA2G2A (0.75) | PLA2G2ABLMCYSLTR2CYSLTR1SMPD1 | |
| SCHEMBL9169101 | 0.78 | PLA2G2A (0.61) | PLA2G2ABLMCYSLTR2CYSLTR1PTPN11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5446189-A | Diester intermediates for diacid enzyme inhibitor | HOFFMANN-LA ROCHE INC. (US) | 1995-08-29 | — | — | US | disclosed |
| US-5324747-A | Treatment of inflammatory diseases | HOFFMANN-LA ROCHE INC. (US) | 1994-06-28 | — | — | US | disclosed |
| EP-0579066-A2 | N-substituted anilines | F. HOFFMANN-LA ROCHE AG (CH) | 1994-01-19 | — | — | EP | disclosed |