Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 8/20 | 0.60 |
| ▸ | BCHE | P06276 | 5/20 | 0.60 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.60 |
| ▸ | TSHR | P16473 | 3/20 | 0.60 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.60 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.60 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.60 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.60 |
| ▸ | CHRM1 | P11229 | 2/20 | 0.60 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.60 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.60 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.60 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.60 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.60 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.60 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.60 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.60 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10631817 | 0.94 | ACHE (0.61) | ACHEBCHEHSD17B10ALDH1A1KDM4E | |
| SCHEMBL9173696 | 0.94 | ACHE (0.61) | ACHEBCHEHSD17B10ALDH1A1KDM4E | |
| SCHEMBL9175875 | 0.93 | ACHE (0.62) | ACHEBCHEHSD17B10ALDH1A1KDM4E | |
| SCHEMBL10634476 | 0.87 | ACHE (0.67) | ACHEBCHEHSD17B10ALDH1A1KDM4E | |
| SCHEMBL10635166 | 0.82 | ACHE (0.68) | ACHEBCHEHSD17B10ALDH1A1KDM4E | |
| SCHEMBL9173090 | 0.82 | ACHE (0.56) | ACHEBCHEHSD17B10ALDH1A1KDM4E | |
| SCHEMBL9175276 | 0.81 | ACHE (0.57) | ACHEBCHEHSD17B10ALDH1A1KDM4E | |
| SCHEMBL9174523 | 0.78 | KMT2A (0.44) | ACHEBCHEKDM4EAPPMEN1 | |
| SCHEMBL10638105 | 0.78 | ACHE (0.67) | ACHEBCHEHSD17B10ALDH1A1KDM4E | |
| SCHEMBL10634443 | 0.78 | ACHE (0.65) | ACHEBCHEGRIN1GRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4762841-A | Substituted 9-amino-spiro(cycloalkyl(b)quinoline-2,1'cycloalkanes) | HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) | 1988-08-09 | — | — | US | claimed |
| EP-0285018-B1 | Substituted 9-Amino-Spiro [cycloalkyl[b]quinoline-2,1'cycloalkanes], a process and intermediates for their preparation and their use as medicaments | HOECHST ROUSSEL PHARMA (US) | 1995-05-31 | — | — | EP | disclosed |
| US-4855479-A | Substituted 9-amino-spiro(cycloalkyl(B)quinoline-2,1'cycloalkanes | SHUTSKE GREGORY M (US) | 1989-08-08 | — | — | US | disclosed |
| US-4806646-A | Substituted 9-amino-spiro[cycloalkyl[B]quinoline-2,1'cycloalkanes] | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-02-21 | — | — | US | disclosed |