Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 2/20 | 0.39 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.35 |
| ▸ | BHMT | Q93088 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | DOT1L | Q8TEK3 | 4/20 | 0.34 |
| ▸ | CARM1 | Q86X55 | 2/20 | 0.34 |
| ▸ | EHMT2 | Q96KQ7 | 2/20 | 0.34 |
| ▸ | DNMT1 | P26358 | 2/20 | 0.34 |
| ▸ | PRMT1 | Q99873 | 2/20 | 0.34 |
| ▸ | DNMT3B | Q9UBC3 | 2/20 | 0.34 |
| ▸ | TRDMT1 | O14717 | 1/20 | 0.34 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.34 |
| ▸ | SUV39H1 | O43463 | 1/20 | 0.34 |
| ▸ | PRMT3 | O60678 | 1/20 | 0.34 |
| ▸ | INMT | O95050 | 1/20 | 0.34 |
| ▸ | NSD2 | O96028 | 1/20 | 0.34 |
| ▸ | PNMT | P11086 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9176272 | 1.00 | NOTUM (0.39) | NOTUMSLC6A5IDO1CYP3A4SLC7A5 | |
| SCHEMBL9177267 | 0.86 | NOTUM (0.41) | NOTUMSLC6A5CYP3A4SLC7A5TSHR | |
| SCHEMBL13401493 | 0.81 | SLC6A5 (0.47) | NOTUMSLC6A5TSHR | |
| SCHEMBL30999504 | 0.81 | TSHR (0.56) | TSHR | |
| SCHEMBL9176257 | 0.81 | TSHR (0.56) | TSHR | |
| SCHEMBL9176248 | 0.81 | TSHR (0.56) | TSHR | |
| SCHEMBL735449 | 0.79 | NOTUM (0.60) | NOTUMTSHRKMT2A | |
| Adenine SCHEMBL9663399 | 0.79 | MARS1 (0.43) | DOT1LCARM1EHMT2DNMT1PRMT1 | |
| SCHEMBL14347081 | 0.78 | SLC6A5 (0.54) | NOTUMSLC6A5TSHR | |
| Adenine SCHEMBL23928076 | 0.78 | MARS1 (0.42) | TSHRDOT1LCARM1EHMT2DNMT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0426467-B1 | Prodrugs of 6-mercaptopurine and 6-thioguanine | WISCONSIN ALUMNI RES FOUND (US) | 1995-04-05 | — | — | EP | disclosed |
| US-5120740-A | PRODRUGS OF 6-MERCAPTOPURINE AND 6-THIOGUANINE | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1992-06-09 | — | — | US | disclosed |
| EP-0426467-A1 | Prodrugs of 6-mercaptopurine and 6-thioguanine | WISCONSIN ALUMNI RESEARCH FOUNDATION (US) | 1991-05-08 | — | — | EP | disclosed |