Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FFAR1 | O14842 | 15/20 | 0.42 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.40 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.40 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | FPR1 | P21462 | 1/20 | 0.38 |
| ▸ | FPR3 | P25089 | 1/20 | 0.38 |
| ▸ | GPR183 | P32249 | 1/20 | 0.38 |
| ▸ | APLNR | P35414 | 1/20 | 0.38 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | GPR65 | Q8IYL9 | 1/20 | 0.38 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.35 |
| ▸ | FDFT1 | P37268 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9180700 | 0.94 | FFAR1 (0.38) | FFAR1CYP4F2CYP4A11CHRM2S1PR1 | |
| SCHEMBL9282160 | 0.89 | CYP4F2 (0.38) | FFAR1CYP4F2CYP4A11CHRM2S1PR1 | |
| SCHEMBL9180384 | 0.88 | CYP4F2 (0.43) | FFAR1CYP4F2CYP4A11CYP4Z1 | |
| SCHEMBL8865334 | 0.87 | CYP3A4 (0.38) | FFAR1CYP4F2CYP4A11FFAR4CYP4Z1 | |
| SCHEMBL9176702 | 0.85 | CYP4Z1 (0.37) | FFAR1CYP4F2CYP4A11CHRM2S1PR1 | |
| SCHEMBL8629224 | 0.84 | RARA (0.42) | — | |
| SCHEMBL9180549 | 0.82 | CYP26A1 (0.43) | FFAR1CHRM2S1PR1FPR1FPR3 | |
| SCHEMBL9177457 | 0.82 | CYP4Z1 (0.40) | FFAR1CYP4F2CYP4A11CYP4Z1 | |
| SCHEMBL8865133 | 0.81 | KMT2A (0.33) | FFAR1CYP4F2CYP4A11 | |
| SCHEMBL8865303 | 0.81 | CYP3A4 (0.36) | FFAR1CYP4F2CYP4A11FFAR4CYP4Z1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0419131-B1 | Acetylenes disubstituted with a phenyl group and a 2-substituted chromanyl, thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity | ALLERGAN INC (US) | 1995-07-05 | — | — | EP | disclosed |
| US-5278318-A | Acetylation under Friedel Crafts condition | ALLERGAN, INC. (US) | 1994-01-11 | — | — | US | disclosed |
| EP-0553156-A4 | CHROMANS AND THIOCHROMANS WITH RETINOID-LIKE ACTIVITY | — | 1993-11-18 | — | — | EP | disclosed |
| EP-0553156-A1 | CHROMANS AND THIOCHROMANS WITH RETINOID-LIKE ACTIVITY | ALLERGAN, INC. (US) | 1993-08-04 | — | — | EP | disclosed |
| US-5162546-A | ACETYLENES DISUBSTITUTED WITH A PHENYL GROUP AND A 2-SUBSTITUTED CHROMANYL, THIOCHROMANYL OR 1,2,3,4-TETRAHYDROQUINOLINYL GROUP HAVING RETINOID-LIKE ACTIVITY | ALLERGAN, INC. (US) | 1992-11-10 | — | — | US | disclosed |
| WO-1992006084-A1 | CHROMANS AND THIOCHROMANS WITH RETINOID-LIKE ACTIVITY | ALLERGAN, INC. (US) | 1992-04-16 | — | — | WO | disclosed |
| EP-0419131-A2 | Acetylenes disubstituted with a phenyl group and a 2-substituted chromanyl, thiochromanyl or 1,2,3,4-tetrahydroquinolinyl group having retinoid-like activity | ALLERGAN, INC. (US) | 1991-03-27 | — | — | EP | disclosed |
| US-4980369-A | ANTIARTHRITIC AGENTS, SKIN DISORDERS, ANTIULCER AGENTS, WOUND HEALING AGENTS | ALLERGAN, INC. (US) | 1990-12-25 | — | — | US | disclosed |