SCHEMBL9178303

SCHEMBL9178303

O=C(O)CCc1cc(Oc2ccc(F)cc2)ccc1CCNS(=O)(=O)c1ccc(Cl)cc1

nearest known ligand 0.60

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
TBXA2R P21731 2/20 0.53
TBXAS1 P24557 6/20 0.53
LMNA P02545 1/20 0.50
MMP1 P03956 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9180208 0.86 TBXAS1 (0.67) TBXA2RTBXAS1LMNA
SCHEMBL9174660 0.85 TBXAS1 (0.61) TBXA2RTBXAS1LMNA
SCHEMBL8592982 0.85 TBXAS1 (0.70) TBXA2RTBXAS1
SCHEMBL9180203 0.82 TBXAS1 (0.53) TBXA2RTBXAS1LMNA
SCHEMBL9177877 0.78 TBXA2R (0.52) TBXA2RTBXAS1
SCHEMBL8595578 0.75 TBXAS1 (0.77) TBXA2RTBXAS1
SCHEMBL9179267 0.74 FNTA (0.46) TBXA2RTBXAS1LMNAMMP1
SCHEMBL8593103 0.73 TBXA2R (0.67) TBXA2RTBXAS1
SCHEMBL8115527 0.73 TBXAS1 (0.63) TBXA2RTBXAS1
SCHEMBL9177656 0.73 TBXA2R (0.52) TBXA2RTBXAS1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0662950-A1 BENZENEALKANOIC ACIDS FOR CARDIOVASCULAR DISEASES Pfizer Limited (GB) 1995-07-19 EP claimed
WO-1994006761-A1 BENZENEALKANOIC ACIDS FOR CARDIOVASCULAR DISEASES PFIZER LIMITED (GB) 1994-03-31 WO claimed