Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.64 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.64 |
| ▸ | HTR1A | P08908 | 1/20 | 0.64 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.64 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9175474 | 0.93 | HTR1A (0.65) | HTR1A | |
| SCHEMBL9179406 | 0.88 | HTR1A (0.67) | ALDH1A1LMNACYP3A4HTR1AALOX12 | |
| SCHEMBL1037297 | 0.85 | — | — | |
| SCHEMBL1038535 | 0.82 | — | — | |
| SCHEMBL9183299 | 0.81 | HTR1A (0.58) | ALDH1A1LMNACYP3A4HTR1AALOX12 | |
| SCHEMBL9176472 | 0.81 | — | — | |
| SCHEMBL9180759 | 0.80 | HTR1A (0.63) | HTR1A | |
| SCHEMBL6173953 | 0.79 | HTR1A (0.65) | HTR1A | |
| SCHEMBL8688384 | 0.79 | HTR1A (0.65) | HTR1A | |
| SCHEMBL31051744 | 0.79 | HTR1A (0.65) | HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0490772-B1 | 1,4-Disubstituted piperazines, their process of preparation and pharmaceutical compositions containing them | ADIR (FR) | 1995-07-26 | — | — | EP | disclosed |
| US-5194437-A | Substituted with oxygen containing heterocycle, central nervous system disorders, neuroendocrine disorders | ADIR ET COMPAGNIE (FR) | 1993-03-16 | — | — | US | disclosed |
| EP-0490772-A1 | 1,4-Disubstituted piperazines, their process of preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1992-06-17 | — | — | EP | disclosed |